Fatty acids induce an increase in the transcription of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA
(HMG-CoA) synthase gene, which encodes an enzyme that has been proposed …

Bax is a pro-apoptotic member of the Bcl-2 family of genes which regulate programmed cell
death. The Bax protein shares highly conserved domains with Bcl-2, some of which are …

Engagement of death receptors such as tumor necrosis factor-R1 and Fas brings about the
cleavage of cytosolic Bid to truncated Bid (tBid), which translocates to mitochondria to …

Resting thymocytes undergoing apoptosis in response to specific stimuli degrade the cdk
inhibitor p27 Kip1 and upregulate Cdk2 kinase activity. Inhibition of Cdk2 kinase activity …

The p53 protein appeared to be involved in both spermatogonial cell proliferation and radiation
response. During normal spermatogenesis in the mouse, spermatogonia do not express …

Bax alpha can heterodimerize with Bcl‐2 and Bcl‐X(L), countering their effects, as well as
promoting apoptosis on overexpression. We show that bax alpha transgenic mice have greatly …

The generation of multiciliated cells ( MCC s) is required for the proper function of many
tissues, including the respiratory tract, brain, and germline. Defects in MCC development have …

Purpose: Trastuzumab-emtansine (T-DM1) is a standard treatment in advanced HER2-positive
breast cancer. However, resistance inevitably occurs. We aimed to identify mechanisms …

1. Abstract 2. Introduction 3. The Bcl-2 family members 4. Biochemical function of the Bcl-2
family members 5. The Bcl-2 family world of protein interactions: 5.1. The classical or direct …

If not properly regulated, the inflammatory immune response can promote carcinogenesis,
as evident in colorectal cancer (CRC). Aiming to gain mechanistic insight into the link …