The endocannabinoid system controls food intake via olfactory processes

…, L Bellocchio, L Reguero, G Lepousez… - Nature …, 2014 - nature.com
Hunger arouses sensory perception, eventually leading to an increase in food intake, but
the underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB …

[PDF][PDF] Adult neurogenesis and the future of the rejuvenating brain circuits

G Lepousez, A Nissant, PM Lledo - Neuron, 2015 - cell.com
For a long time, the mammalian brain has been perceived to be a static organ. However, the
discovery of adult neurogenesis in most mammalian species, including humans, monkeys, …

Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons

G Lepousez, A Nissant, AK Bryant… - Proceedings of the …, 2014 - National Acad Sciences
The production of new neurons in the olfactory bulb (OB) through adulthood is a major
mechanism of structural and functional plasticity underlying learning-induced circuit remodeling. …

[HTML][HTML] Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

…, A Messager, F Leulier, G Lepousez… - Nature …, 2020 - nature.com
Depression is the leading cause of disability worldwide. Recent observations have revealed
an association between mood disorders and alterations of the intestinal microbiota. Here, …

Bacterial sensing via neuronal Nod2 regulates appetite and body temperature

I Gabanyi, G Lepousez, R Wheeler, A Vieites-Prado… - Science, 2022 - science.org
Gut bacteria influence brain functions and metabolism. We investigated whether this influence
can be mediated by direct sensing of bacterial cell wall components by brain neurons. In …

Activation of adult-born neurons facilitates learning and memory

M Alonso, G Lepousez, S Wagner, C Bardy… - Nature …, 2012 - nature.com
Thousand of local interneurons reach the olfactory bulb of adult rodents every day, but the
functional effect of this process remains elusive. By selectively expressing channelrhodopsin …

Two-photon probes for in vivo multicolor microscopy of the structure and signals of brain cells

…, CX He, C Portera-Cailliau, G Lepousez… - Brain Structure and …, 2018 - Springer
Imaging the brain of living laboratory animals at a microscopic scale can be achieved by two-photon
microscopy thanks to the high penetrability and low phototoxicity of the excitation …

Somatostatinergic systems in brain: networks and functions

C Viollet, G Lepousez, C Loudes, C Videau… - Molecular and cellular …, 2008 - Elsevier
Somatostatin is abundantly expressed in mammalian brain. The peptide binds with high
affinity to six somatostatin receptors, sst1, sst2A and B, sst3 to 5, all belonging to the G-protein-…

The impact of adult neurogenesis on olfactory bulb circuits and computations

G Lepousez, MT Valley, PM Lledo - Annual review of physiology, 2013 - annualreviews.org
Modern neuroscience has demonstrated how the adult brain has the ability to profoundly
remodel its neurons in response to changes in external stimuli or internal states. However, …

[PDF][PDF] Odor discrimination requires proper olfactory fast oscillations in awake mice

G Lepousez, PM Lledo - Neuron, 2013 - cell.com
Gamma oscillations are commonly observed in sensory brain structures, notably in the
olfactory bulb. The mechanism by which gamma is generated in the awake rodent and its …