The endocannabinoid system controls food intake via olfactory processes
…, L Bellocchio, L Reguero, G Lepousez… - Nature …, 2014 - nature.com
Hunger arouses sensory perception, eventually leading to an increase in food intake, but
the underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB …
the underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB …
[PDF][PDF] Adult neurogenesis and the future of the rejuvenating brain circuits
G Lepousez, A Nissant, PM Lledo - Neuron, 2015 - cell.com
For a long time, the mammalian brain has been perceived to be a static organ. However, the
discovery of adult neurogenesis in most mammalian species, including humans, monkeys, …
discovery of adult neurogenesis in most mammalian species, including humans, monkeys, …
Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons
G Lepousez, A Nissant, AK Bryant… - Proceedings of the …, 2014 - National Acad Sciences
The production of new neurons in the olfactory bulb (OB) through adulthood is a major
mechanism of structural and functional plasticity underlying learning-induced circuit remodeling. …
mechanism of structural and functional plasticity underlying learning-induced circuit remodeling. …
[HTML][HTML] Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system
…, A Messager, F Leulier, G Lepousez… - Nature …, 2020 - nature.com
Depression is the leading cause of disability worldwide. Recent observations have revealed
an association between mood disorders and alterations of the intestinal microbiota. Here, …
an association between mood disorders and alterations of the intestinal microbiota. Here, …
Bacterial sensing via neuronal Nod2 regulates appetite and body temperature
I Gabanyi, G Lepousez, R Wheeler, A Vieites-Prado… - Science, 2022 - science.org
Gut bacteria influence brain functions and metabolism. We investigated whether this influence
can be mediated by direct sensing of bacterial cell wall components by brain neurons. In …
can be mediated by direct sensing of bacterial cell wall components by brain neurons. In …
Activation of adult-born neurons facilitates learning and memory
M Alonso, G Lepousez, S Wagner, C Bardy… - Nature …, 2012 - nature.com
Thousand of local interneurons reach the olfactory bulb of adult rodents every day, but the
functional effect of this process remains elusive. By selectively expressing channelrhodopsin …
functional effect of this process remains elusive. By selectively expressing channelrhodopsin …
Two-photon probes for in vivo multicolor microscopy of the structure and signals of brain cells
…, CX He, C Portera-Cailliau, G Lepousez… - Brain Structure and …, 2018 - Springer
Imaging the brain of living laboratory animals at a microscopic scale can be achieved by two-photon
microscopy thanks to the high penetrability and low phototoxicity of the excitation …
microscopy thanks to the high penetrability and low phototoxicity of the excitation …
Somatostatinergic systems in brain: networks and functions
C Viollet, G Lepousez, C Loudes, C Videau… - Molecular and cellular …, 2008 - Elsevier
Somatostatin is abundantly expressed in mammalian brain. The peptide binds with high
affinity to six somatostatin receptors, sst1, sst2A and B, sst3 to 5, all belonging to the G-protein-…
affinity to six somatostatin receptors, sst1, sst2A and B, sst3 to 5, all belonging to the G-protein-…
The impact of adult neurogenesis on olfactory bulb circuits and computations
Modern neuroscience has demonstrated how the adult brain has the ability to profoundly
remodel its neurons in response to changes in external stimuli or internal states. However, …
remodel its neurons in response to changes in external stimuli or internal states. However, …
[PDF][PDF] Odor discrimination requires proper olfactory fast oscillations in awake mice
G Lepousez, PM Lledo - Neuron, 2013 - cell.com
Gamma oscillations are commonly observed in sensory brain structures, notably in the
olfactory bulb. The mechanism by which gamma is generated in the awake rodent and its …
olfactory bulb. The mechanism by which gamma is generated in the awake rodent and its …