Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is
tuned to perform diverse biochemical functions. The absence of a consensus sequence that …

Endogenous ligands for cannabinoid receptors ("endocannabinoids") include the lipid
transmitters anandamide and 2-arachidonoylglycerol (2-AG). Endocannabinoids modulate a …

In the past decade, there have been remarkable advances in proteomic technologies. Mass
spectrometry has emerged as the preferred method for in-depth characterization of the …

N-Acyl ethanolamines (NAEs) are a large class of signaling lipids implicated in diverse
physiological processes, including nociception, cognition, anxiety, appetite, and inflammation. It …

Proteolysis is a key regulatory process that promotes the (in)activation, translocation, and/or
degradation of proteins. As such, there is considerable interest in methods to …

N-Acyl ethanolamines (NAEs) constitute a large and diverse class of signaling lipids that
includes the endogenous cannabinoid anandamide. Like other lipid transmitters, NAEs are …

To study how microbes establish themselves in a mammalian gut environment, we colonized
germ-free mice with microbial communities from human, zebrafish, and termite guts, human …

Genome sequencing projects have uncovered thousands of uncharacterized enzymes in
eukaryotic and prokaryotic organisms. Deciphering the physiological functions of enzymes …

Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …

Serine hydrolases (SHs) are one of the largest and most diverse enzyme classes in mammals.
They play fundamental roles in virtually all physiological processes and are targeted by …