User profiles for Gabriel M. Simon
Gabriel SimonVP of Discovery at Vividion Therapeutics Verified email at vividion.com Cited by 8937 |
Quantitative reactivity profiling predicts functional cysteines in proteomes
Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is
tuned to perform diverse biochemical functions. The absence of a consensus sequence that …
tuned to perform diverse biochemical functions. The absence of a consensus sequence that …
[PDF][PDF] A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
JL Blankman, GM Simon, BF Cravatt - Chemistry & biology, 2007 - cell.com
Endogenous ligands for cannabinoid receptors ("endocannabinoids") include the lipid
transmitters anandamide and 2-arachidonoylglycerol (2-AG). Endocannabinoids modulate a …
transmitters anandamide and 2-arachidonoylglycerol (2-AG). Endocannabinoids modulate a …
The biological impact of mass-spectrometry-based proteomics
In the past decade, there have been remarkable advances in proteomic technologies. Mass
spectrometry has emerged as the preferred method for in-depth characterization of the …
spectrometry has emerged as the preferred method for in-depth characterization of the …
[HTML][HTML] Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for α/β-hydrolase 4 in this pathway
GM Simon, BF Cravatt - Journal of Biological Chemistry, 2006 - ASBMB
N-Acyl ethanolamines (NAEs) are a large class of signaling lipids implicated in diverse
physiological processes, including nociception, cognition, anxiety, appetite, and inflammation. It …
physiological processes, including nociception, cognition, anxiety, appetite, and inflammation. It …
[HTML][HTML] Global mapping of the topography and magnitude of proteolytic events in apoptosis
MM Dix, GM Simon, BF Cravatt - Cell, 2008 - cell.com
Proteolysis is a key regulatory process that promotes the (in)activation, translocation, and/or
degradation of proteins. As such, there is considerable interest in methods to …
degradation of proteins. As such, there is considerable interest in methods to …
Inactivation of N-Acyl Phosphatidylethanolamine Phospholipase D Reveals Multiple Mechanisms for the Biosynthesis of Endocannabinoids
N-Acyl ethanolamines (NAEs) constitute a large and diverse class of signaling lipids that
includes the endogenous cannabinoid anandamide. Like other lipid transmitters, NAEs are …
includes the endogenous cannabinoid anandamide. Like other lipid transmitters, NAEs are …
[PDF][PDF] Bacteria from diverse habitats colonize and compete in the mouse gut
To study how microbes establish themselves in a mammalian gut environment, we colonized
germ-free mice with microbial communities from human, zebrafish, and termite guts, human …
germ-free mice with microbial communities from human, zebrafish, and termite guts, human …
[HTML][HTML] Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study
GM Simon, BF Cravatt - Journal of Biological Chemistry, 2010 - ASBMB
Genome sequencing projects have uncovered thousands of uncharacterized enzymes in
eukaryotic and prokaryotic organisms. Deciphering the physiological functions of enzymes …
eukaryotic and prokaryotic organisms. Deciphering the physiological functions of enzymes …
[PDF][PDF] An activity-guided map of electrophile-cysteine interactions in primary human T cells
Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …
on immune cells. These compounds are thought to act by cysteine modification to alter the …
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening
Serine hydrolases (SHs) are one of the largest and most diverse enzyme classes in mammals.
They play fundamental roles in virtually all physiological processes and are targeted by …
They play fundamental roles in virtually all physiological processes and are targeted by …