Cytosolic DNA sensing is an important process during the innate immune response that
activates the stimulator of interferon genes (STING) adaptor and induces IFN-I. STING incites …

Pronuclear formation, and the chromosomal constitution and developmental capacity of
bovine zygotes formed by intracytoplasmic sperm injection with freeze-dried (lyophilized) …

Cytosolic DNA sensing via the stimulator of IFN genes (STING) adaptor incites autoimmunity
by inducing type I IFN (IFN-αβ). In this study, we show that DNA is also sensed via STING to …

Cytosolic DNA sensing activates the stimulator of IFN genes (STING) adaptor to induce IFN
type I (IFN-αβ) production. Constitutive DNA sensing to induce sustained STING activation …

Neuropathic pain is one of the most important clinical consequences of injury to the
somatosensory system. Nevertheless, the critical pathophysiological mechanisms involved in …

Increased pain sensitivity is a comorbidity associated with many clinical diseases, though
the underlying causes are poorly understood. Recently, chronic pain hypersensitivity in …

Typically, embryonic stem (ES) cells derived from 129 mouse substrains are used to generate
genetically altered mouse models. Resulting chimeric mice were then usually converted to …

A series of experiments was conducted to test the hypothesis that an improved cryopreservation
protocol for pronuclear stage mouse embryos will produce transgenic (Tg) mice by …

The International Mouse Knockout Consortium aims to generate a knockout mouse for every
single gene on a C57BL/6 background. Our ability to generate such mice is hampered by …

Immune activation complicates HIV despite antiretroviral therapy (ART). Indoleamine 2,3
dioxygenase (IDO) catabolizes tryptophan (T) to kynurenine (K), regulating immune activity, and …