User profiles for Gabriella N. L. Chua

Gabriella NL Chua

The Rockefeller University
Verified email at rockefeller.edu
Cited by 106

When force met fluorescence: single-molecule manipulation and visualization of protein–DNA interactions

GNL Chua, S Liu - Annual Review of Biophysics, 2024 - annualreviews.org
Myriad DNA-binding proteins undergo dynamic assembly, translocation, and conformational
changes while on DNA or alter the physical configuration of the DNA substrate to control its …

Cytosine-based TET enzyme inhibitors

GNL Chua, KL Wassarman, H Sun, JA Alp… - ACS medicinal …, 2019 - ACS Publications
DNA methylation is known as the prima donna epigenetic mark for its critical role in
regulating local gene transcription. Changes in the landscape of DNA methylation across the …

Single-stranded nucleic acid binding and coacervation by linker histone H1

R Leicher, A Osunsade, GNL Chua… - Nature structural & …, 2022 - nature.com
The H1 linker histone family is the most abundant group of eukaryotic chromatin-binding
proteins. However, their contribution to chromosome structure and function remains …

[HTML][HTML] Differential dynamics specify MeCP2 function at methylated DNA and nucleosomes

GNL Chua, JW Watters, PDB Olinares, JA Luo… - BioRxiv, 2023 - ncbi.nlm.nih.gov
Methyl-CpG-binding protein 2 (MeCP2) is an essential chromatin-binding protein whose
mutations cause Rett syndrome (RTT), a leading cause of monogenic intellectual disabilities in …

Students' Perspective on Scientific Training

GNL Chua, JJ Vandana, CC Hsieh - ChemBioChem, 2023 - Wiley Online Library
Chua, Vandana, and Hsieh discuss the needs of graduate students and ways to cultivate
purposeful, personalized mentee training in the lab. … Chua, Vandana, and Hsieh discuss …

Single-molecule dissection of the interaction between a methyl-DNA binding protein and chromatin

GNL Chua - Biophysical Journal, 2023 - cell.com
The methyl-CpG binding protein 2 (MeCP2) is a prominent DNA methylation reader that is
essential for proper gene expression programming and normal functioning of nerve cells. …

Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA

GNL Chua, S Liu - Biophysical Journal, 2024 - cell.com
Methyl-CpG-binding protein 2 (MeCP2) is an essential chromatin-binding protein whose
mutations cause Rett syndrome (RTT), a leading cause of monogenic intellectual disabilities in …

[PDF][PDF] Single-stranded nucleic acid sensing and coacervation by linker histone H1

R Leicher, A Osunsade, GNL Chua, SC Faulkner… - Biophysical …, 2022 - cell.com
The linker histone H1 family is the most abundant group of eukaryotic chromatinbinding
proteins, in which H1 is known for its role as a nucleosome compactor and an essential …

Why nucleosome breathing dynamics is asymmetric?

A Mondal, AB Kolomeisky - Biophysical Journal, 2024 - cell.com
In eukaryotic cells, DNA is bound to nucleosome particles, allowing for chromatin to be efficiently
confined in small cellular volumes. But these compact structures are not rigid, and DNA …

Uncoating of HIV-1 capsid is regulated by long double-stranded DNA products of reverse transcription and nucleocapsid protein-mediated DNA condensation

M Morse, RC Burdick, I Rouzina, VK Pathak… - Biophysical …, 2024 - cell.com
We show that HIV capsid uncoating occurs after nuclear import and completion of reverse
transcription. Furthermore, capsid uncoating efficiency is correlated with viral genome size, …