BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair

G Sessa, B Gómez‐González, S Silva… - The EMBO …, 2021 - embopress.org
The BRCA2 tumor suppressor is a DNA double‐strand break (DSB) repair factor essential
for maintaining genome integrity. BRCA2‐deficient cells spontaneously accumulate DNA‐…

[HTML][HTML] Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

…, M Julien, FX Theillet, V Ropars, G Sessa… - Nature …, 2020 - nature.com
The BRCA2 tumor suppressor protein is involved in the maintenance of genome integrity
through its role in homologous recombination. In mitosis, BRCA2 is phosphorylated by Polo-…

A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin

B Gómez-González, G Sessa, A Carreira… - Molecular & Cellular …, 2021 - Taylor & Francis
In a recent report, we have revealed a new interaction between the BRCA2 DNA repair
associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes …

The phospho-dependent role of BRCA2 on the maintenance of chromosome integrity

Å Ehlén, G Sessa, S Zinn-Justin, A Carreira - Cell Cycle, 2021 - Taylor & Francis
Chromosomal instability is a hallmark of cancer. The tumor suppressor protein BRCA2 performs
an important role in the maintenance of genome integrity particularly in interphase; as a …

[HTML][HTML] Missense Variants of Uncertain Significance: A Powerful Genetic Tool for Function Discovery with Clinical Implications

G Sessa, Å Ehlén, C von Nicolai, A Carreira - Cancers, 2021 - mdpi.com
Simple Summary Variants of uncertain significance in the breast cancer susceptibility gene
BRCA2 represent 50–80% of the results from genetic testing. These mutations may lead to …

[PDF][PDF] Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

VB Theillet, G Sessa, R Beaurepere, V Boucherit… - researchgate.net
The BRCA2 tumor suppressor protein is involved in the maintenance of genome integrity
through its role in homologous recombination. In mitosis, BRCA2 is phosphorylated by Pololike …

Role of the Interaction of BRCA2 and DDX5 in the DNA Damage Response

G Sessa - 2020 - theses.hal.science
Increasing evidence support the idea that proteins involved in RNA metabolism such as
RNA binding proteins (RBPs) and RNA helicases are directly implicated in the DNA damage …

Cumulative contents

…, U Christians, D Leibfritz, A Di Stefano, R La Gaetana… - core.ac.uk
Sessa, P. Tunici, E. Rabellotti, S. … La Gaetana, L. Bovalini, P. Lusini and P. …

Polymyalgia rheumatica and diverticular disease: just two distinct age-related disorders or more? Results from a case-control study

R Scrivo, MC Gerardi, I Rutigliano, P Sessa… - Clinical …, 2018 - Springer
In a previous report of two married cohabiting couples affected by polymyalgia rheumatica (PMR),
we noticed that the wife of one couple and both members of the other couple suffered …

Maria Gaetana Agnesi: Mathematics and the making of the catholic enlightenment

M Mazzotti - Isis, 2001 - journals.uchicago.edu
Maria Gaetana Agnesi (1718-1799) is known as the author of a textbook on calculus that
appeared in Milan in 1748. For the first time a woman was able to establish herself as a …