[PDF][PDF] In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions
S Quenneville, G Verde, A Corsinotti, A Kapopoulou… - Molecular cell, 2011 - cell.com
The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during
early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57, …
early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57, …
[HTML][HTML] Hypomethylation at multiple maternally methylated imprinted regions including PLAGL1 and GNAS loci in Beckwith–Wiedemann syndrome
J Bliek, G Verde, J Callaway, SM Maas… - European Journal of …, 2009 - nature.com
Genomic imprinting is an epigenetic phenomenon restricting gene expression in a manner
dependent on parent of origin. Imprinted gene products are critical regulators of growth and …
dependent on parent of origin. Imprinted gene products are critical regulators of growth and …
Inherited and Sporadic Epimutations at the IGF2-H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumor
The parent-of-origin-dependent expression of IGF2 and H19 is controlled by the imprinting
center 1 (IC1) consisting of a methylation-sensitive chromatin insulator. IC1 is normally …
center 1 (IC1) consisting of a methylation-sensitive chromatin insulator. IC1 is normally …
Origins of DNA methylation defects in Wilms tumors
Wilms tumor is an embryonic renal cancer that typically presents in early childhood and
accounts for 7% of all paediatric cancers. Different genetic alterations have been described in …
accounts for 7% of all paediatric cancers. Different genetic alterations have been described in …
[HTML][HTML] Distinct Methylation Changes at the IGF2-H19 Locus in Congenital Growth Disorders and Cancer
A Murrell, Y Ito, G Verde, J Huddleston, K Woodfine… - PloS one, 2008 - journals.plos.org
Background Differentially methylated regions (DMRs) are associated with many imprinted
genes. In mice methylation at a DMR upstream of the H19 gene known as the Imprint Control …
genes. In mice methylation at a DMR upstream of the H19 gene known as the Imprint Control …
Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith–Wiedemann syndrome and Wilms' tumour
F Cerrato, A Sparago, G Verde… - Human molecular …, 2008 - academic.oup.com
The parent of origin-dependent expression of the IGF2 and H19 genes is controlled by the
imprinting centre 1 (IC1) consisting in a methylation-sensitive chromatin insulator. Deletions …
imprinting centre 1 (IC1) consisting in a methylation-sensitive chromatin insulator. Deletions …
ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells
…, M Cammisa, H Kukreja, Z Anvar, G Verde… - Nucleic acids …, 2016 - academic.oup.com
ZFP57 is necessary for maintaining repressive epigenetic modifications at Imprinting control
regions (ICRs). In mouse embryonic stem cells (ESCs), ZFP57 binds ICRs (ICR BS ) and …
regions (ICRs). In mouse embryonic stem cells (ESCs), ZFP57 binds ICRs (ICR BS ) and …
[PDF][PDF] PLK1 signaling in breast cancer cells cooperates with estrogen receptor-dependent gene transcription
M Wierer, G Verde, P Pisano, H Molina, J Font-Mateu… - Cell reports, 2013 - cell.com
Polo-like kinase 1 (PLK1) is a key regulator of cell division and is overexpressed in many
types of human cancers. Compared to its well-characterized role in mitosis, little is known …
types of human cancers. Compared to its well-characterized role in mitosis, little is known …
Hormone-control regions mediate steroid receptor–dependent genome organization
…, R Ferrari, LI De Llobet, G Verde… - Genome …, 2019 - genome.cshlp.org
In breast cancer cells, some topologically associating domains (TADs) behave as hormonal
gene regulation units, within which gene transcription is coordinately regulated in response …
gene regulation units, within which gene transcription is coordinately regulated in response …
[HTML][HTML] LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells
…, G Serra-Bardenys, J Querol, M Cosín, G Verde… - Oncogene, 2020 - nature.com
Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3
modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher …
modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher …