Glycogen synthase kinase-3 (GSK3) is now recognized as a key component of a surprisingly
large number of cellular processes and diseases. Several mechanisms play a part in …

Tau is a group of neuronal microtubule-associated proteins that are formed by alternative
mRNA splicing and accumulate in neurofibrillary tangles in Alzheimer's disease (AD) brain. …

The microtubule-associated protein tau, abundant in neurons, has gained notoriety due to the
fact that it is deposited in cells as fibrillar lesions in numerous neurodegenerative diseases…

Huntington's disease (HD) is initiated by an abnormally expanded polyglutamine stretch in
the huntingtin protein, conferring a novel property on the protein that leads to the loss of …

The p38 mitogen‐activated protein kinase is a stress‐activated enzyme responsible for
transducing inflammatory signals and initiating apoptosis. In the Alzheimer's disease (AD) brain, …

Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …

Histone deacetylase 6 (HDAC6), a unique cytoplasmic deacetylase, likely plays a role in
neurodegeneration by coordinating cell responses to abnormal protein aggregation. Here, we …

Paired helical filaments (PHFs) are the major structural elements of Alzheimer's disease
neurofibrillary lesions, and these filaments are formed from hyperphosphorylated brain tau …

Glycogen synthase kinase 3β (GSK3β) phosphorylates substrates, including the microtubule-associated
protein tau, at both primed and unprimed epitopes. GSK3β phosphorylation of …

Site‐specific phosphorylation of tau negatively regulates its ability to bind and stabilize
microtubule structure. Although tau is a substrate of glycogen synthase kinase 3β (GSK3β), the …