Polyketides are among the major classes of bioactive natural products used to treat microbial
infections, cancer, and other diseases. Here we describe a pathway to chloroethylmalonyl-…

The increased levels of extracellular DNA found in a number of disorders involving
dysregulation of the fibrinolytic system may affect interactions between fibrinolytic enzymes and …

The first elongation step of fatty acid biosynthesis by a type II dissociated fatty acid synthases
is catalyzed by 3-ketoacyl-acyl carrier protein (ACP) synthase III (KASIII, FabH). This …

The formation of an activated cis-3-cyclohexylpropenoic acid by Plm1, the first extension
module of the phoslactomycin polyketide synthase, is proposed to occur through an L-3-…

The first step of the reaction catalyzed by the homodimeric FabH from a dissociated fatty acid
synthase is acyl transfer from acyl-CoA to an active site cysteine. We report that C 1 to C 10 …

The marine Streptomyces sp. CNQ-617 produces two diastereomers, marineosins A and B.
These are structurally related to alkyl prodiginines, but with a more complex cyclization and …

Malonyl acyl carrier protein (ACP) is used as an extender unit in each of the elongation
steps catalyzed by the type II dissociated fatty acid synthase (FAS) and polyketide synthase (PKS…

Background: The long term survival outcome of patients with IPF is bleak, with a paucity of
effective treatments. Results: The changes in baseline PAI-1 expression regulate fibroblast …

Recent studies have shed new light on the role of the fibrinolytic system in the pathogenesis
of pleural organization, including the mechanisms by which the system regulates …

Prodiginines are a class of red-pigmented natural products with immunosuppressant, anticancer,
and antimalarial activities. Recent studies on prodiginine biosynthesis in Streptomyces …