IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction

C Westwell-Roper, DL Dai, G Soukhatcheva… - The journal of …, 2011 - journals.aai.org
Islets from patients with type 2 diabetes exhibit β cell dysfunction, amyloid deposition,
macrophage infiltration, and increased expression of proinflammatory cytokines and chemokines. …

Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver

…, M Beach, R Cullum, S Lee, G Soukhatcheva… - Genome …, 2010 - genome.cshlp.org
The liver and pancreas share a common origin and coexpress several transcription factors.
To gain insight into the transcriptional networks regulating the function of these tissues, we …

[HTML][HTML] Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

J Montane, L Bischoff, G Soukhatcheva… - The Journal of …, 2011 - Am Soc Clin Investig
CD4+ CD25+ Foxp3+ Tregs play a major role in prevention of autoimmune diseases. The
suppressive effect of Tregs on effector T cells (Teffs), the cells that can mediate autoimmunity, …

Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in β-cells

L Marzban, G Soukhatcheva, CB Verchere - Endocrinology, 2005 - academic.oup.com
Islet amyloid polypeptide (IAPP; amylin) is a peptide hormone that is cosecreted with insulin
from β-cells. Impaired processing of proIAPP, the IAPP precursor, has been implicated in …

Kinetics and genomic profiling of adult human and mouse β-cell maturation

M Szabat, P Pourghaderi, G Soukhatcheva… - Islets, 2011 - Taylor & Francis
Diabetes is a multifactorial metabolic disorder defined by the loss of functional pancreatic
insulin-producing β-cells. The functional maturation and dedifferentiation of adult β-cells is …

CCL22 prevents rejection of mouse islet allografts and induces donor-specific tolerance

…, L Bischoff, DL Dai, G Soukhatcheva… - Cell …, 2015 - journals.sagepub.com
Manipulation of regulatory T cell (Treg) migration by islet expression of the chemokine
CCL22 prevents diabetes in NOD mice and delays recurrent autoimmunity in syngeneic islet …

Cellular mechanisms of CCL22-mediated attenuation of autoimmune diabetes

…, S Alvarez, DL Dai, G Soukhatcheva… - The Journal of …, 2015 - journals.aai.org
Autoimmune destruction of insulin-producing β cells in type 1 diabetes and islet transplantation
involves a variety of immune pathways but is primarily mediated by self-reactive T cells. …

Role of the TLR signaling molecule TRIF in β-cell function and glucose homeostasis

MJH Hutton, G Soukhatcheva, JD Johnson… - Islets, 2010 - Taylor & Francis
Type 2 diabetes is a metabolic and inflammatory disease characterized by deteriorating islet
function and increased levels of inflammatory cytokines. The inflammatory milieu induced in …

[HTML][HTML] ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice

…, C Westwell-Roper, D Nackiewicz, G Soukhatcheva… - Diabetologia, 2016 - Springer
Aims/hypothesis Islet amyloid, a pathological feature of type 2 diabetes, forms from the
aggregation of islet amyloid polypeptide (IAPP), a beta cell peptide that is produced and co-…

Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction

…, H Yu, GJ Bakker, M Winkelmeijer, G Soukhatcheva… - Gut …, 2022 - Taylor & Francis
Hyperglycemia and type 2 diabetes (T2D) are caused by failure of pancreatic beta cells.
The role of the gut microbiota in T2D has been studied, but causal links remain enigmatic. …