User profiles for Gamze Gursoy
 | Gamze GürsoyColumbia University Verified email at columbia.edu Cited by 4731 |
[PDF][PDF] Data sanitization to reduce private information leakage from functional genomics
The generation of functional genomics datasets is surging, because they provide insight into
gene regulation and organismal phenotypes (eg, genes upregulated in cancer). The intent …
gene regulation and organismal phenotypes (eg, genes upregulated in cancer). The intent …
[HTML][HTML] Unique toll-like receptor 4 activation by NAMPT/PBEF induces NFκB signaling and inflammatory lung injury
Ventilator-induced inflammatory lung injury (VILI) is mechanistically linked to increased
NAMPT transcription and circulating levels of nicotinamide phosphoribosyl-transferase (NAMPT/…
NAMPT transcription and circulating levels of nicotinamide phosphoribosyl-transferase (NAMPT/…
Functional genomics data: privacy risk assessment and technological mitigation
The generation of functional genomics data by next-generation sequencing has increased
greatly in the past decade. Broad sharing of these data is essential for research advancement …
greatly in the past decade. Broad sharing of these data is essential for research advancement …
Spatial confinement is a major determinant of the folding landscape of human chromosomes
The global architecture of the cell nucleus and the spatial organization of chromatin play
important roles in gene expression and nuclear function. Single-cell imaging and chromosome …
important roles in gene expression and nuclear function. Single-cell imaging and chromosome …
[HTML][HTML] An integrative ENCODE resource for cancer genomics
ENCODE comprises thousands of functional genomics datasets, and the encyclopedia
covers hundreds of cell types, providing a universal annotation for genome interpretation. …
covers hundreds of cell types, providing a universal annotation for genome interpretation. …
Computational construction of 3D chromatin ensembles and prediction of functional interactions of alpha-globin locus from 5C data
Conformation capture technologies measure frequencies of interactions between chromatin
regions. However, understanding gene-regulation require knowledge of detailed spatial …
regions. However, understanding gene-regulation require knowledge of detailed spatial …
[HTML][HTML] Using Ethereum blockchain to store and query pharmacogenomics data via smart contracts
Background As pharmacogenomics data becomes increasingly integral to clinical treatment
decisions, appropriate data storage and sharing protocols need to be adopted. One …
decisions, appropriate data storage and sharing protocols need to be adopted. One …
[HTML][HTML] Recurrent repeat expansions in human cancer genomes
Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to
cause more than 50 diseases 1 , 2 . However, repeat expansions are often not explored …
cause more than 50 diseases 1 , 2 . However, repeat expansions are often not explored …
Fast and scalable private genotype imputation using machine learning and partially homomorphic encryption
The recent advances in genome sequencing technologies provide unprecedented opportunities
to understand the relationship between human genetic variation and diseases. However…
to understand the relationship between human genetic variation and diseases. However…
[HTML][HTML] Using blockchain to log genome dataset access: efficient storage and query
G Gürsoy, R Bjornson, ME Green, M Gerstein - BMC medical genomics, 2020 - Springer
Background Genomic variants are considered sensitive information, revealing potentially
private facts about individuals. Therefore, it is important to control access to such data. A key …
private facts about individuals. Therefore, it is important to control access to such data. A key …