Tumorigenesis is a multistep process involving co-operation between several deregulated
oncoproteins. In this study, we unravel previously unrecognized interactions and crosstalk …

Among the biomedical efforts in response to the current coronavirus (COVID-19) pandemic,
pharmacological strategies to reduce viral load in patients with severe forms of the disease …

Phenothiazines (PTZ) were developed as inhibitors of monoamine neurotransmitter receptors,
notably dopamine receptors. Because of this activity they have been used for decades as …

Simple Summary Trafficking chaperones facilitate the spatio-temporal distribution pattern of
proteins inside cells. In the case of the membrane-anchored protein Ras, trafficking …

Recently, the highly mutated oncoprotein K-Ras4B (hereafter K-Ras) was shown to drive
cancer cell stemness in conjunction with calmodulin (CaM). We previously showed that the …

The small GTPase Ras is frequently mutated in cancer and a driver of tumorigenesis. The
recent years have shown great progress in drug-targeting Ras and understanding how it …

The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a
surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in …

Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their
capability to emit phosphorescence in the kinase-bound state was established. Labelling of the …

A previously disclosed protein kinase (PK) CK2-selective inhibitor 4-(2-amino-1,3-thiazol-5-yl)benzoic
acid (ATB) and its selenium-containing counterpart (ASB) revealed remarkable …

The acknowledged potential of small-molecule therapeutics targeting disease-related
protein–protein interactions (PPIs) has promoted active research in this field. The strategy of using …