Hyperactive signaling of the MAP kinase pathway resulting from the constitutively active B-Raf
V600E mutated enzyme has been observed in a number of human tumors, including …

Vancomycin is a recommended therapy in multiple national guidelines. Despite the common
use, there is a poor understanding of the mechanistic drivers and potential modifiers of …

Objectives Tenofovir disoproxil fumarate/emtricitabine ( TDF / FTC ) is approved for pre‐exposure
prophylaxis (Pr EP ) against HIV infection. Adherence is critical for the success of Pr …

Aim In view of the increasing prevalence of obesity in adolescents, the aim of this study was
to determine the pharmacokinetics of the CYP3A substrate midazolam and its metabolites in …

Cefepime is a fourth-generation cephalosporin antibiotic with an extended spectrum of
activity against many Gram-positive and Gram-negative bacteria. There is a growing need to …

Purpose: Currently, <50% of high-risk pediatric solid tumors like neuroblastoma can be cured,
and many survivors experience serious or life-threatening toxicities, so more effective, less …

Background: With the increasing prevalence of multidrug resistant organisms, therapeutic
drug monitoring (TDM) has become a common tool for assuring the safety and efficacy of …

GW844520 is a potent and selective inhibitor of the cytochrome bc1 complex of mitochondrial
electron transport in P. falciparum, the parasite primarily responsible for the mortality …

Voriconazole is a broad-spectrum antifungal triazole drug for the treatment of invasive fungal
infections. It is extensively metabolized by hepatic drug metabolizing enzymes cytochrome (…

Metal-oxide nanoparticles (MO-NPs), such as the highly bioreactive copper-based nanoparticles
(CuO-NPs), are widely used in manufacturing of hundreds of commercial products. …