User profiles for Ganna Reint
 | Ganna ReintVerified email at broadinstitute.org Cited by 63 |
[PDF][PDF] Optimization of Cas12a for multiplexed genome-scale transcriptional activation
Cas12a CRISPR technology, unlike Cas9, allows for facile multiplexing of guide RNAs from
a single transcript, simplifying combinatorial perturbations. While Cas12a has been …
a single transcript, simplifying combinatorial perturbations. While Cas12a has been …
Rapid genome editing by CRISPR-Cas9-POLD3 fusion
Precision CRISPR gene editing relies on the cellular homology-directed DNA repair (HDR)
to introduce custom DNA sequences to target sites. The HDR editing efficiency varies …
to introduce custom DNA sequences to target sites. The HDR editing efficiency varies …
Kidney development and perspectives for organ engineering
Organ transplantation is currently the best strategy for treating end stage renal disease (ESRD)
but the numbers of donor kidneys available are not sufficient to meet the needs of the …
but the numbers of donor kidneys available are not sufficient to meet the needs of the …
Spontaneous formation and rearrangement of artificial lipid nanotube networks as a bottom-up model for endoplasmic reticulum
We present a convenient method to form a bottom-up structural organelle model for the
endoplasmic reticulum (ER). The model consists of highly dense lipidic nanotubes that are, in …
endoplasmic reticulum (ER). The model consists of highly dense lipidic nanotubes that are, in …
Deciphering the minimal quantity of mouse primary cells to undergo nephrogenesis ex vivo
A Rak‐Raszewska, G Reint, F Geiger… - Developmental …, 2022 - Wiley Online Library
Background Tissue organoids derived from primary cells have high potential for studying
organ development and diseases in numerous organs. They recreate the morphological …
organ development and diseases in numerous organs. They recreate the morphological …
[HTML][HTML] Protocol for editing fibroblasts with in vitro transcribed Cas9 mRNA and profile off-target editing by optimized GUIDE-seq
Z Li, G Reint, EM Haapaniemi - STAR protocols, 2023 - Elsevier
CRISPR-Cas9 gene editing is an efficient technique to modify specific sites/regions of DNA.
Delivery of the Cas9 by mRNA is particularly promising in pre-clinical genome editing …
Delivery of the Cas9 by mRNA is particularly promising in pre-clinical genome editing …
[PDF][PDF] Ganna Reint, Aleksandra Rak-Raszewska
SJ Vainio - researchgate.net
Organ transplantation is currently the best strategy for treating end stage renal disease (ESRD)
but the numbers of donor kidneys available are not sufficient to meet the needs of the …
but the numbers of donor kidneys available are not sufficient to meet the needs of the …
Current status and future prospects of decellularized kidney tissue
Y Nishimura - Journal of Artificial Organs, 2023 - Springer
End-stage renal disease (ESRD) is characterized by progressive loss of kidney function,
which can result in damage to various tissues and organs. Dialysis therapy and kidney …
which can result in damage to various tissues and organs. Dialysis therapy and kidney …
[HTML][HTML] Engraftment of Kidney Organoids In Vivo
BS Freedman, B Dekel - Current Transplantation Reports, 2023 - Springer
Purpose of Review Kidney organoids are heterocellular structures grown in vitro that resemble
nephrons. Organoids contain diverse cell types, including podocytes, proximal tubules, …
nephrons. Organoids contain diverse cell types, including podocytes, proximal tubules, …
[HTML][HTML] From genetics to personalized nephrology: kidney research at a tipping point
TB Huber, H Holthofer - Cell and Tissue Research, 2017 - Springer
Technologies for genetic analysis continue their evolution at an amazing pace, including
advances in whole genome sequencing, total RNA sequencing and single cell genomics. …
advances in whole genome sequencing, total RNA sequencing and single cell genomics. …