Three members of the Rho family, Cdc42, Rac, and Rho are known to regulate the organization
of actin-based cytoskeletal structures. In Bac1.2F5 macrophages, we have shown that …

We describe a localization microscopy analysis method that is able to extract results in live
cells using standard fluorescent proteins and xenon arc lamp illumination. Our Bayesian …

Rho family proteins are known to regulate actin organization in fibroblasts, but their functions
in cells of haematopoietic origin have not been studied in detail. Bac1.2F5 cells are a …

Neutrophil transmigration through venular walls that are composed of endothelial cells (ECs),
pericytes, and the venular basement membrane is a key component of innate immunity. …

The cellular mechanisms that configure the cytoskeleton during migration of dendritic cells (DCs)
are poorly understood. Immature DCs assemble specialized adhesion structures …

Networks of actin filaments, controlled by the Arp2/3 complex, drive membrane protrusion
during cell migration. How integrins signal to the Arp2/3 complex is not well understood. Here, …

The actin cytoskeleton is regulated by Rho family proteins: in fibroblasts, Rho mediates the
formation of actin stress fibers, whereas Rac regulates lamellipodium formation and Cdc42 …

Whereas most cells in adult tissues are fixed in place by cell junctions, leukocytes are motile
and able to migrate actively through the walls of blood vessels into surrounding tissues. The …

Severe congenital neutropenia (SCN) is characterized by neutropenia, recurrent bacterial
infections, and maturation arrest in the bone marrow. Although many cases have mutations in …

… Franz,1,2 Gareth E. Jones,3 and Anne J. Ridley1,2,4 1Ludwig Institute for Cancer
Research Royal Free and University College School … of cell-cell junctions, and in particular …