[HTML][HTML] Hyperinsulinemia drives diet-induced obesity independently of brain insulin production
AE Mehran, NM Templeman, GS Brigidi, GE Lim… - Cell metabolism, 2012 - cell.com
Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether
insulin causes these phenomena or is a compensatory response has remained unsettled for …
insulin causes these phenomena or is a compensatory response has remained unsettled for …
Glucagon-like peptide 1 secretion by the L-cell: the view from within
GE Lim, PL Brubaker - Diabetes, 2006 - Am Diabetes Assoc
Glucagon-like peptide 1 (GLP-1) is a gut-derived peptide secreted from intestinal L-cells
after a meal. GLP-1 has numerous physiological actions, including potentiation of glucose-…
after a meal. GLP-1 has numerous physiological actions, including potentiation of glucose-…
Prenatal exposure to nicotine causes postnatal obesity and altered perivascular adipose tissue function
YJ Gao, AC Holloway, ZH Zeng, GE Lim… - Obesity …, 2005 - Wiley Online Library
Objective: Recent epidemiological studies have shown that there is an increased risk of obesity
and hypertension in children born to women who smoked during pregnancy. The aim of …
and hypertension in children born to women who smoked during pregnancy. The aim of …
Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell
GE Lim, GJ Huang, N Flora, D LeRoith… - …, 2009 - academic.oup.com
Insulin resistance and type 2 diabetes mellitus are associated with impaired postprandial
secretion of glucagon-like peptide-1 (GLP-1), a potent insulinotropic hormone. The direct …
secretion of glucagon-like peptide-1 (GLP-1), a potent insulinotropic hormone. The direct …
[HTML][HTML] A causal role for hyperinsulinemia in obesity
Insulin modulates the biochemical pathways controlling lipid uptake, lipolysis and lipogenesis
at multiple levels. Elevated insulin levels are associated with obesity, and conversely, …
at multiple levels. Elevated insulin levels are associated with obesity, and conversely, …
Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells
The proglucagon gene (glu) encodes the incretin hormone glucagon-like peptide-1 (GLP-1),
produced in the intestinal endocrine L cells. We found previously that the bipartite …
produced in the intestinal endocrine L cells. We found previously that the bipartite …
[PDF][PDF] Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan
The causal relationships between insulin levels, insulin resistance, and longevity are not
fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling …
fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling …
[HTML][HTML] Identification of biomarkers for glycaemic deterioration in type 2 diabetes
We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing
2,973 individuals across three molecular classes, metabolites, lipids and proteins. …
2,973 individuals across three molecular classes, metabolites, lipids and proteins. …
[HTML][HTML] 14-3-3ζ coordinates adipogenesis of visceral fat
The proteins that coordinate complex adipogenic transcriptional networks are poorly
understood. 14-3-3ζ is a molecular adaptor protein that regulates insulin signalling and …
understood. 14-3-3ζ is a molecular adaptor protein that regulates insulin signalling and …
[HTML][HTML] Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain
…, AP Chiu, DA Dionne, DF Hutchinson, GE Lim… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Excess circulating insulin is associated with obesity in humans and in animal models.
However, the physiologic causality of hyperinsulinemia in adult obesity has rightfully been …
However, the physiologic causality of hyperinsulinemia in adult obesity has rightfully been …