Lipocalin 2 (LCN2) is a pleiotropic molecule that is induced in the central nervous system (CNS)
in several acute and chronic pathologies. The acute induction of LCN2 evolved as a …

Genome-wide mapping of histone modifications is critical to understanding transcriptional
regulation. CUT&Tag is a new method for profiling histone modifications, offering improved …

Colony stimulating factor 3 receptor (CSF3R) mutations lead to JAK pathway activation and
are the molecular hallmark of chronic neutrophilic leukemia (CNL). Approximately half of …

Animal development proceeds in the presence of intimate microbial associations, but the
extent to which different host cells across the body respond to resident microbes remains to be …

Responses to kinase-inhibitor therapy in AML are frequently short-lived due to the rapid
development of resistance, limiting the clinical efficacy. Combination therapy may improve initial …

For decades, molecular biologists have been uncovering the mechanics of biological systems.
Efforts to bring their findings together have led to the development of multiple databases …

Acute myeloid leukemia (AML) is a deadly blood cancer characterized by an overproduction
of immature myeloid cells. AML has a high degree of genetic diversity, and the presence or …

This work establishes the synergistic efficacy of combined FLT3 and LSD1 inhibition in FLT3-ITD
AML by disrupting STAT5 and GFI1 binding at the MYC blood-specific superenhancer …

Activating mutations in the KIT tyrosine receptor kinase confer an adverse prognosis for
patients with acute myeloid leukemia (AML). Successful treatment options are limited, as kinase …

Background The rapid advancement of new genomic sequencing technology has enabled
the development of multi-omic single-cell sequencing assays. These assays profile multiple …