User profiles for Gary A. Churchill
Gary ChurchillThe Jackson Laboratory Verified email at jax.org Cited by 53490 |
Empirical threshold values for quantitative trait mapping.
GA Churchill, RW Doerge - Genetics, 1994 - academic.oup.com
The detection of genes that control quantitative characters is a problem of great interest to the
genetic mapping community. Methods for locating these quantitative trait loci (QTL) relative …
genetic mapping community. Methods for locating these quantitative trait loci (QTL) relative …
R/qtl: QTL mapping in experimental crosses
R/qtl is an extensible, interactive environment for mapping quantitative trait loci (QTLs) in
experimental populations derived from inbred lines. It is implemented as an add-on package for …
experimental populations derived from inbred lines. It is implemented as an add-on package for …
Stochastic models for heterogeneous DNA sequences
GA Churchill - Bulletin of mathematical biology, 1989 - Elsevier
The composition of naturally occurring DNA sequences is often strikingly heterogeneous. In
this paper, the DNA sequence is viewed as a stochastic process with local compositional …
this paper, the DNA sequence is viewed as a stochastic process with local compositional …
[HTML][HTML] Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
…, JP Palazzo, OI Olopade, PS Bernard, GA Churchill… - Genome biology, 2007 - Springer
Background Although numerous mouse models of breast carcinomas have been developed,
we do not know the extent to which any faithfully represent clinically significant human …
we do not know the extent to which any faithfully represent clinically significant human …
A Hidden Markov Model approach to variation among sites in rate of evolution.
J Felsenstein, GA Churchill - Molecular biology and evolution, 1996 - academic.oup.com
The method of Hidden Markov Models is used to allow for unequal and unknown evolutionary
rates at different sites in molecular sequences. Rates of evolution at different sites are …
rates at different sites in molecular sequences. Rates of evolution at different sites are …
Analysis of variance for gene expression microarray data
MK Kerr, M Martin, GA Churchill - Journal of computational biology, 2000 - liebertpub.com
Spotted cDNA microarrays are emerging as a powerful and cost-effective tool for large-scale
analysis of gene expression. Microarrays can be used to measure the relative quantities of …
analysis of gene expression. Microarrays can be used to measure the relative quantities of …
Fundamentals of experimental design for cDNA microarrays
GA Churchill - Nature genetics, 2002 - nature.com
Microarray technology is now widely available and is being applied to address increasingly
complex scientific questions. Consequently, there is a greater demand for statistical …
complex scientific questions. Consequently, there is a greater demand for statistical …
[HTML][HTML] Statistical tests for differential expression in cDNA microarray experiments
X Cui, GA Churchill - Genome biology, 2003 - Springer
Extracting biological information from microarray data requires appropriate statistical methods.
The simplest statistical method for detecting differential expression is the t test, which can …
The simplest statistical method for detecting differential expression is the t test, which can …
Experimental design for gene expression microarrays
MK Kerr, GA Churchill - Biostatistics, 2001 - academic.oup.com
We examine experimental design issues arising with gene expression microarray technology.
Microarray experiments have multiple sources of variation, and experimental plans should …
Microarray experiments have multiple sources of variation, and experimental plans should …
Variation in gene expression within and among natural populations
Evolution may depend more strongly on variation in gene expression than on differences
between variant forms of proteins 1. Regions of DNA that affect gene expression are highly …
between variant forms of proteins 1. Regions of DNA that affect gene expression are highly …