Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer
cell survival. We show that, in human lung cancer cells, acute increases in intracellular …

Thioredoxin-interacting protein (TXNIP) is an α-arrestin family protein that is induced in response
to glucose elevation. It has been shown to provide a negative feedback loop to regulate …

The pyruvate kinase M2 isoform (PKM2) is expressed in cancer and plays a role in regulating
anabolic metabolism. To determine whether PKM2 is required for tumor formation or growth…

Metabolic regulation influences cell proliferation. The influence of pyruvate kinase isoforms
on tumor cells has been extensively studied, but whether PKM2 is required for normal cell …

Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association
with increased survival in patients with cancer taking metformin; however, the mechanism …

Here, we show that a subset of breast cancers express high levels of the type 2
phosphatidylinositol-5-phosphate 4-kinases α and/or β (PI5P4Kα and β) and provide evidence that …

We previously reported that combining a phosphoinositide 3-kinase (PI3K) inhibitor with a
poly-ADP Rib polymerase (PARP)-inhibitor enhanced DNA damage and cell death in breast …

Purpose: DNA methylation in human papillomavirus–associated (HPV + ) head and neck
squamous cell carcinoma (HNSCC) may have importance for continuous expression of HPV …

The ERBB2/HER2/NEU receptor tyrosine kinase gene is amplified in up to 30% of human
breast cancers. The frequent and specific selection of this receptor kinase gene for …

CUB domain-containing protein 1 (CDCP1) is a transmembrane protein that is highly
expressed in stem cells and frequently overexpressed and tyrosine-phosphorylated in cancer. …