Reductions in cerebral metabolism sufficient to impair cognition in normal individuals also
occur in Alzheimer's disease (AD). The degree of clinical disability in AD correlates closely to …

Resveratrol, a polyphenol found in red wine, peanuts, soy beans, and pomegranates, possesses
a wide range of biological effects. Since resveratrol's properties seem ideal for treating …

• A report of cell loss in the nucleus basalis of Meynert in patients with Wernicke-Korsakoff
disease prompted the examination of thiamine pyrophosphate (TPP)-dependent enzymes in …

: Several lines of evidence support the role of oxidative stress, including increased lipid
peroxidation, in the pathogenesis of Alzheimer's disease (AD). Lipid peroxidation generates …

The recent demonstration of K+ channel dysfunction in fibroblasts from Alzheimer disease (AD)
patients and past observations of Ca(2+)-mediated K+ channel modulation during …

Presenilin-1 (PS1) and −2 (PS2), which when mutated cause familial Alzheimer disease, have
been localized to numerous compartments of the cell, including the endoplasmic reticulum…

We studied a thiamine-requiring enzyme in cultured cells from four patients with the
Wernicke-Korsakoff syndrome to determine whether these patients have a genetic predilection to …

Many aspects of calcium homeostasis change with aging. Numerous calcium compartments
complicate studies of altered calcium regulation. However, age-related decreases in …

Hypoxia is commonly invoked to explain alterations in mental function, particularly in patients
with cardiac or pulmonary failure. The effects of acute graded hypoxia on higher integrative …

Recent etiological study in twins (Tanner et al. 1999) strongly suggests that environmental
factors play an important role in typical, non‐familial Parkinson's disease (PD), beginning after …