Background Since anecdotal series and small, prospective, controlled trials suggest that
mycophenolate mofetil may be effective for treating lupus nephritis, larger trials are desirable. …

Tristetraprolin (TTP) is a widely expressed potential transcription factor that contains two
unusual CCCH zinc fingers and is encoded by the immediate–early response gene, Zfp-36. …

Evidence from animal models and prospective studies of RA, multiple sclerosis, and type-1
diabetes suggest an important role for vitamin D as a modifiable environmental factor in …

Objective To determine the safety and efficacy of allogeneic mesenchymal stem cell
transplantation (MSCT) in refractory systemic lupus erythematosus (SLE). Methods A total of 15 …

Objective Umbilical cord (UC)–derived mesenchymal stem cells (MSCs) have shown marked
therapeutic effects in a number of diseases in animal studies, based on their potential for …

Studies in human systemic lupus erythematosus (SLE) suggest a possible role for histone
deacetylases (HDACs) in skewed gene expression and disease pathogenesis. We used the …

We previously produced three congenic strains carrying lupus susceptibility genes (Sle1-Sle3)
from the lupus-prone NZM2410 mouse on the C57BL/6 background and characterized …

MRL-lpr/lpr mice spontaneously develop various manifestations of autoimmunity including
an inflammatory arthropathy and immune complex glomerulonephritis. This study examines …

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass
index (BMI), predominantly in populations of European ancestry. We conducted a meta-…

We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of
systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The …