Aging is associated with impaired vascular endothelial function, as indicated in part by
reduced endothelium-dependent dilation (EDD). Decreased EDD with aging is thought to be …

We tested the hypothesis that vascular endothelial function, assessed by endothelium-dependent
dilation, is related to serum vitamin D status among middle-aged and older adults …

Context: Vitamin D insufficiency/deficiency is commonly observed in black youth. Objective:
The aim was to determine 25-hydroxyvitamin D [25(OH)D] in response to 2000 IU vitamin D …

Background— We tested the hypothesis that nuclear factor-κB (NF-κB) activity contributes to
vascular endothelial dysfunction with aging and obesity in humans. Methods and Results— …

Cellular senescence is emerging as a key mechanism of age-related vascular endothelial
dysfunction, but evidence in healthy humans is lacking. Moreover, the influence of lifestyle …

Key points • Advancing age is the major risk factor for the development of cardiovascular
diseases. • Arterial endothelial dysfunction, characterized by impaired endothelium‐dependent …

Age is the major risk factor for cardiovascular diseases (CVD) and this is attributable in part
to stiffening of large elastic arteries and development of vascular endothelial dysfunction (eg …

Brachial artery FMD (flow-mediated dilation) is impaired with aging and is associated with
an increased risk of CVD (cardiovascular disease). In the present study, we determined …

Telomere length (TL), a measure of replicative senescence, decreases with aging, but the
factors involved are incompletely understood. To determine if age-associated reductions in TL …

The objective of this study was to investigate the effects of 12 weeks of standard cardiac
rehabilitation on endothelial function, oxidative stress, and antioxidant defenses in patients with …