Histone acetylation and deacetylation were found to be catalyzed by structurally distinct,
multisubunit complexes that mediate, respectively, activation and repression of transcription. …

The requirements for transcriptional activation by RNA polymerase II were examined using
chromatin templates assembled in vitro and a transcription system composed of the human …

Regulation of biological processes typically incorporates mechanisms that initiate and terminate
the process and, where understood, these mechanisms often involve feedback control. …

Posttranslational histone modifications are crucial for the modulation of chromatin structure
and regulation of transcription. Bromodomains present in many chromatin-associated …

Mononucleosomes, the basic building blocks of chromatin, contain two copies of each core
histone. The associated posttranslational modifications regulate essential chromatin-…

Cancer is a disease consisting of both genetic and epigenetic changes. Although increasing
evidence demonstrates that tumour progression entails chromatin-mediated changes such …

It is unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly
growing tumors. We found that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1), …

Transcription of naked DNA in vitro requires the general transcription factors and RNA
polymerase II. However, this minimal set of factors is not sufficient for transcription when the DNA …

Small-molecule BET inhibitors interfere with the epigenetic interactions between acetylated
histones and the bromodomains of the BET family proteins, including BRD4, and they …

Methylation of specific histone residues is capable of both gene activation and silencing.
Despite vast work on the function of methylation, most studies either present a static snapshot of …