Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

CC Nixon, M Mavigner, GC Sampey, AD Brooks… - Nature, 2020 - nature.com
Long-lasting, latently infected resting CD4 + T cells are the greatest obstacle to obtaining a
cure for HIV infection, as these cells can persist despite decades of treatment with …

[HTML][HTML] Exosomes from HIV-1-infected cells stimulate production of pro-inflammatory cytokines through trans-activating response (TAR) RNA

GC Sampey, M Saifuddin, A Schwab, R Barclay… - Journal of Biological …, 2016 - ASBMB
HIV-1 infection results in a chronic illness because long-term highly active antiretroviral
therapy can lower viral titers to an undetectable level. However, discontinuation of therapy …

[HTML][HTML] Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein

…, M Saifuddin, R Das, PV Afonso, GC Sampey… - Journal of Biological …, 2014 - ASBMB
Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia
and HTLV-1-associated myelopathy/tropical spastic paraparesis. The HTLV-1 transactivator …

Exosomes and their role in CNS viral infections

GC Sampey, SS Meyering, M Asad Zadeh… - Journal of …, 2014 - Springer
Exosomes are small membrane-bound vesicles that carry biological macromolecules from
the site of production to target sites either in the microenvironment or at distant sites away …

[HTML][HTML] Ebola VP40 in exosomes can cause immune cell dysfunction

…, A Schwab, S Iordanskiy, GC Sampey… - Frontiers in …, 2016 - frontiersin.org
Ebola virus (EBOV) is an enveloped, ssRNA virus from the family Filoviridae capable of
causing severe hemorrhagic fever with up to 80–90% mortality rates. The most recent outbreak …

[HTML][HTML] Presence of viral RNA and proteins in exosomes from cellular clones resistant to rift valley fever virus infection

NA Ahsan, GC Sampey, Y Akpamagbo… - Frontiers in …, 2016 - frontiersin.org
Rift Valley Fever Virus (RVFV) is a RNA virus that belongs to the genus Phlebovirus, family
Bunyaviridae. It infects humans and livestock and causes Rift Valley fever. RVFV is …

[HTML][HTML] Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells

S Iordanskiy, R Van Duyne, GC Sampey, CM Woodson… - Virology, 2015 - Elsevier
The highly active antiretroviral therapy reduces HIV-1 RNA in plasma to undetectable levels.
However, the virus continues to persist in the long-lived resting CD4 + T cells, macrophages …

Novel neuroprotective GSK-3β inhibitor restricts Tat-mediated HIV-1 replication

…, M Saifuddin, R Das, E Jaworski, GC Sampey… - Journal of …, 2014 - Am Soc Microbiol
The implementation of new antiretroviral therapies targeting transcription of early viral
proteins in postintegrated HIV-1 can aid in overcoming current therapy limitations. Using high-…

Production and purification of Bacillus anthracis protective antigen from Escherichia coli

…, D Zukauskas, K Johnson, GC Sampey… - Protein expression and …, 2004 - Elsevier
Anthrax is caused by the gram-positive, spore-forming bacterium, Bacillus anthracis. The
anthrax toxin consists of three proteins, protective antigen (PA), lethal factor, and edema factor. …

[HTML][HTML] Complex role of microRNAs in HTLV-1 infections

GC Sampey, R Van Duyne, R Currer, R Das… - Frontiers in …, 2012 - frontiersin.org
Human T-lymphotropic virus 1 (HTLV-1) was the first human retrovirus to be discovered and
is the causative agent of adult T-cell leukemia/lymphoma (ATL) and the neurodegenerative …