In recent years, scientists have created artificial microscopic and nanoscopic self-propelling
particles, often referred to as nano- or microswimmers, capable of mimicking biological …

Blood-mediated nanoparticle delivery is a new and growing field in the development of
therapeutics and diagnostics. Nanoparticle properties such as size, shape and surface chemistry …

Mycobacterium tuberculosis is a major pathogen that has the ability to establish, and emerge
from, a persistent state. Wbl family proteins are associated with developmental processes …

The blood-brain barrier is made of polarized brain endothelial cells (BECs) phenotypically
conditioned by the central nervous system (CNS). Although transport across BECs is of …

Due to the absence of curative treatments for glioblastoma (GBM), we assessed the efficacy
of single and combination treatments with a translationally relevant 2nd generation TRAIL-…

The influence of 3D microenvironments on apoptosis susceptibility remains poorly
understood. Here, we studied the susceptibility of cancer cell spheroids, grown to the size of …

The execution phase of apoptosis is a critical process in programmed cell death in response
to a multitude of cellular stresses. A crucial component of this pathway is the apoptosome, a …

Cellular signalling is a vital process in living organisms for coordinating highly diverse
responses to various stimuli. Particle-based modelling excels in its ability to model complex …

Glioblastoma (GBM) is the most malignant and aggressive form of glioma and is associated
with a poor survival rate. Latest generation Tumour Necrosis Factor Related Apoptosis-…

One of the most promising task is the ability to engineer nanocarriers that can autonomously
navigate within tissues and organs, accessing nearly every site of the human body guided …