In addition to protein coding sequence, the human genome contains a significant amount of
regulatory DNA, the identification of which is proving somewhat recalcitrant to both in silico …

Background Despite the short length of their reads, micro-read sequencing technologies
have shown their usefulness for de novo sequencing. However, especially in eukaryotic …

Determining the underlying haplotypes of individual human genomes is an essential, but
currently difficult, step toward a complete understanding of genome function. Fosmid pool-…

Independent determination of both haplotype sequences of an individual genome is essential
to relate genetic variation to genome function, phenotype, and disease. To address the …

Germline colonization by retroviruses results in the formation of endogenous retroviruses (ERVs).
Most colonization’s occurred millions of years ago. However, in the Australo-Papuan …

Comparisons between diverse vertebrate genomes have uncovered thousands of highly
conserved non-coding sequences, an increasing number of which have been shown to …

Determining species distributions can be extremely challenging but is crucial to ecological
and conservation research. Environmental DNA (eDNA) approaches have shown particular …

Fish–mammal genomic comparisons have proved powerful in identifying conserved
noncoding elements likely to be cis-regulatory in nature, and the majority of those tested in vivo …

Spillover of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) to North
American white-tailed deer (Odocoileus virginianus) has been documented. However, it is …

Repeated retroviral infections of vertebrate germlines have made endogenous retroviruses
ubiquitous features of mammalian genomes. However, millions of years of evolution obscure …