Synthetic oligosaccharides and glycoconjugates are increasingly used as probes for biological
research and as lead compounds for drug and vaccine discovery. These endeavours are…

Sialic acids are a diverse family of naturally occurring 2-keto-3-deoxy-nononic acids that are
involved in a wide range of biological processes. 1, 2 The C-5-amino derivative represents …

Major histocompatibility complex (MHC) class I and II are glycoproteins that can present
antigenic peptides at the cell surface for recognition and activation of circulating T lymphocytes. …

Azides, which are extremely rare in biological systems, are emerging as attractive chemical
handles for bioconjugation.[1–5] In particular, the CuI catalyzed 1, 3-dipolar cyclization of …

Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly pneumonia
worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein, which …

A systematic, efficient means of producing diverse libraries of asymmetrically branched N-glycans
is needed to investigate the specificities and biology of glycan-binding proteins. To …

Glycoconjugatcs arc the moht t ‘unctionally and structurally diverse molecules in nature and
it is now well established that protein-and lipid-bound saccharides play essential roles in …

Phototriggering of the metal-free azide to acetylene cycloaddition reaction was achieved by
masking the triple bond of dibenzocyclooctynes as cyclopropenone. Such masked …

The overexpression of saccharides such as Globo-H, Lewis Y and Tn antigen is a common
feature of oncogenic transformed cells. Endeavors to exploit this aberrant glycosylation for …

Human betacoronaviruses OC43 and HKU1 are endemic respiratory pathogens and, while
related, originated from independent zoonotic introductions. OC43 is in fact a host-range …