Abnormal chromosome content — also known as aneuploidy — is the most common characteristic
of human solid tumours. It has therefore been proposed that aneuploidy contributes to…

… Geert JPL Kops Geert JPL Kops … Third, phosphorylation might affect the stability of the
protein but FOXO factors appear to be highly stable [the half-life of FOXO4 is >10 h (GJPL Kops, …

The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

The Forkhead transcription factors AFX, FKHR and FKHR-L1 are orthologues of DAF-16, a
Forkhead factor that regulates longevity in Caenorhabditis elegans 1 , 2 , 3 . Here we show …

Reactive oxygen species are required for cell proliferation but can also induce apoptosis 1 .
In proliferating cells this paradox is solved by the activation of protein kinase B (PKB; also …

The phosphatidylinositol-3-OH-kinase (PI(3)K) effector protein kinase B ( 1 , 2 ) regulates
certain insulin-responsive genes 3 , 4 , but the transcription factors regulated by protein kinase …

Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human
intestinal stem cells can be cultured in medium containing the stem-cell-niche factors WNT, …

The cytokine IL-2 plays a very important role in the proliferation and survival of activated T
cells. These effects of IL-2 are dependent on signaling through the phosphatidylinositol 3-…

Various types of chromosomal aberrations, including numerical (aneuploidy) and structural (eg,
translocations, deletions), are commonly found in human tumors and are linked to …

AFX-like Forkhead transcription factors, which are controlled by phosphatidylinositol 3-kinase
(PI3K)/protein kinase B (PKB) signaling, are involved in regulating cell cycle progression …