Azides, which are extremely rare in biological systems, are emerging as attractive chemical
handles for bioconjugation.[1–5] In particular, the CuI catalyzed 1, 3-dipolar cyclization of …

Synthetic oligosaccharides and glycoconjugates are increasingly used as probes for biological
research and as lead compounds for drug and vaccine discovery. These endeavours are…

Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly pneumonia
worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein, which …

The overexpression of saccharides such as Globo-H, Lewis Y and Tn antigen is a common
feature of oncogenic transformed cells. Endeavors to exploit this aberrant glycosylation for …

Emerging evidence suggests that host glycans influence severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. Here, we reveal that the receptor-binding domain (…

The bioorthogonal chemical reporter strategy is emerging as a versatile method for the
labeling of biomolecules, such as nucleic acids, lipids, carbohydrates, and proteins.[1] In this …

Glycoconjugatcs arc the moht t ‘unctionally and structurally diverse molecules in nature and
it is now well established that protein-and lipid-bound saccharides play essential roles in …

The principal challenge that the synthesis of oligosaccharides of biological importance
presents is the development of a general approach for the stereoselective introduction of a …

Human betacoronaviruses OC43 and HKU1 are endemic respiratory pathogens and, while
related, originated from independent zoonotic introductions. OC43 is in fact a host-range …

… Lin Liu; Pradeep Chopra; Xiuru Li; Kim M Bouwman; Stephen Mark Tompkins; Margreet
A Wolfert; Robert P de Vries; Geert-Jan Boons. … Geert-Jan Boons; University of Georgia …