In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42 has
been developed from regulatory proteins that regulate specific actin cytoskeletal structures …

… Aman (2003T3201) and van Nieuw Amerongen’s (2011T072) institutions … van Nieuw
Amerongen received support for travel from the Dutch Heart Foundation. Dr. van Nieuw Amerongen …

… Author links open overlay panel Geerten P. van Nieuw Amerongen a , Victor WM van …
Recent research has identified several new promising targets for pharmacological therapy. …

Decreased tissue perfusion increases the risk of developing insulin resistance and cardiovascular
disease in obesity, and decreased levels of globular adiponectin (gAdn) have been …

Endothelial cells (ECs) actively regulate the extravasation of blood constituents. On stimulation
by vasoactive agents and thrombin, ECs change their cytoskeletal architecture and small …

In the present study, we differentiated between short- and long-term effects of vasoactive
compounds on human endothelial permeability in an in vitro model. Histamine induced a rapid …

In the present study, the roles of the small GTPase RhoA and its target Rho kinase in endothelial
permeability were investigated in vitro. We have shown previously that, in addition to a …

Background—Recent clinical trials have established that inhibitors of the enzyme 3-hydroxy-3-methylglutaryl
coenzyme A reductase (statins) reduce the risk of acute coronary events. …

Objective— Growth factor-induced angiogenesis involves migration of endothelial cells (ECs)
into perivascular areas and requires active remodeling of the endothelial F-actin …

Rationale: Altered pulmonary hemodynamics and fluid flow–induced high shear stress (HSS)
are characteristic hallmarks in the pathogenesis of pulmonary arterial hypertension (PAH). …