A wide variety of microbial and inflammatory factors induce DNA release from neutrophils
as neutrophil extracellular traps (NETs). Consensus on the kinetics and mechanism of NET …

Objectives Increased release of neutrophil extracellular traps (NETs) is implicated in the
activation of plasmacytoid dendritic cells, vascular disease and thrombosis in SLE and APS. …

Myeloid cells play a crucial role in controlling infection. Activation of these cells needs to be
tightly regulated, because their potent effector functions can damage host tissue. Inhibitory …

BackgroundSince cytomegalovirus (CMV) infection can cause serious clinical complications
in immunocompromised individuals, we assessed cellular immune requirements for …

ROS production is an important effector mechanism mediating intracellular killing of microbes
by phagocytes. Inappropriate or untimely ROS production can lead to tissue damage, thus …

Since CMV-specific T-cells have been shown to generally express an advanced state of
differentiation, we investigated whether these mature CMV-specific T-cells are sustained in HIV-…

… were incubated with SIRL-1-HA-Flag or LAIR-1-HA-Flag recombinant proteins bound to anti-…
with anti-HA agarose (Sigma) at 4C overnight. The next day, anti-HA agarose was washed …

Background Expression quantitative trait loci (eQTL) databases represent a valuable resource
to link disease-associated SNPs to specific candidate genes whose gene expression is …

Signal inhibitory receptor on leukocytes‐1 (SIRL‐1) is a negative regulator of myeloid cell
function and dampens antimicrobial responses. We here show that different species of the …

Background: HIV-1-infected children have an increased risk of severe chickenpox. However,
vaccination is not recommended in severely immunocompromised children. Objective: Can …