User profiles for Gemma F Codner
Gemma CodnerSenior Research Facilitator in Epidemiology Verified email at ndph.ox.ac.uk Cited by 1701 |
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium
…, S Greenaway, D Sneddon, H Morgan, GF Codner… - Nature …, 2017 - nature.com
Although next-generation sequencing has revolutionized the ability to associate variants with
human diseases, diagnostic rates and development of new therapies are still limited by a …
human diseases, diagnostic rates and development of new therapies are still limited by a …
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics
The function of the majority of genes in the mouse and human genomes remains unknown.
The mouse embryonic stem cell knockout resource provides a basis for the characterization …
The mouse embryonic stem cell knockout resource provides a basis for the characterization …
Microhomologies are prevalent at Cas9-induced larger deletions
…, AJ Allan, A Bucakci, L Greder, GF Codner… - Nucleic acids …, 2019 - academic.oup.com
The CRISPR system is widely used in genome editing for biomedical research. Here, using
either dual paired Cas9 D10A nickases or paired Cas9 nuclease we characterize …
either dual paired Cas9 D10A nickases or paired Cas9 nuclease we characterize …
[HTML][HTML] Analysing the outcome of CRISPR-aided genome editing in embryos: Screening, genotyping and quality control
The application of CRISPR/Cas9 technology has revolutionised genetics by greatly enhancing
the efficacy of genome editing in the early embryo. Furthermore, the system has enabled …
the efficacy of genome editing in the early embryo. Furthermore, the system has enabled …
[HTML][HTML] Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants
Background Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) genome editing have led to the use of long …
protein 9 (Cas9) genome editing have led to the use of long …
A resource of targeted mutant mouse lines for 5,061 genes
The International Mouse Phenotyping Consortium reports the generation of new mouse
mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel …
mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel …
Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse
The suprachiasmatic nucleus (SCN) coordinates circadian rhythms that adapt the individual
to solar time. SCN pacemaking revolves around feedback loops in which expression of …
to solar time. SCN pacemaking revolves around feedback loops in which expression of …
[HTML][HTML] Long-read sequencing for fast and robust identification of correct genome-edited alleles: PCR-based and Cas9 capture methods
CV McCabe, PD Price, GF Codner, AJ Allan… - Plos …, 2024 - journals.plos.org
Background Recent developments in CRISPR/Cas9 genome-editing tools have facilitated
the introduction of precise alleles, including genetic intervals spanning several kilobases, …
the introduction of precise alleles, including genetic intervals spanning several kilobases, …
Clarin‐2 is essential for hearing by maintaining stereocilia integrity and function
…, P Jeyarajan, S Morse, A Lelli, GF Codner… - EMBO Molecular …, 2019 - embopress.org
Hearing relies on mechanically gated ion channels present in the actin‐rich stereocilia bundles
at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying …
at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying …
[HTML][HTML] Aneuploidy screening of embryonic stem cell clones by metaphase karyotyping and droplet digital polymerase chain reaction
Background Karyotypic integrity is essential for the successful germline transmission of
alleles mutated in embryonic stem (ES) cells. Classical methods for the identification of …
alleles mutated in embryonic stem (ES) cells. Classical methods for the identification of …