User profiles for Gen Ohtsuki

Gen Ohtsuki

Kyoto University Graduate School of Medicine
Verified email at kyoto-u.ac.jp
Cited by 1304

[PDF][PDF] Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning

…, HJ Boele, BJ van Beugen, Z Gao, A Badura, G Ohtsuki… - Neuron, 2010 - cell.com
Cerebellar motor learning is required to obtain procedural skills. Studies have provided
supportive evidence for a potential role of kinase-mediated long-term depression (LTD) at the …

[PDF][PDF] Microglia-triggered plasticity of intrinsic excitability modulates psychomotor behaviors in acute cerebellar inflammation

M Yamamoto, M Kim, H Imai, Y Itakura, G Ohtsuki - Cell reports, 2019 - cell.com
Cerebellar dysfunction relates to various psychiatric disorders, including autism spectrum
and depressive disorders. However, the physiological aspect is less advanced. Here, we …

Bidirectional plasticity at developing climbing fiber–Purkinje neuron synapses

G Ohtsuki, T Hirano - European Journal of Neuroscience, 2008 - Wiley Online Library
Climbing fibers provide one of the two major excitatory inputs to the cerebellar cortex. In an
immature animal, several climbing fibers form synapses with one Purkinje neuron. During …

Enhanced inhibitory synaptic transmission in the cerebellar molecular layer of the GluRδ2 knock-out mouse

G Ohtsuki, S Kawaguchi, M Mishina… - Journal of …, 2004 - Soc Neuroscience
A novel ionotropic glutamate receptor subunit δ2 (GluRδ2), which is specifically expressed
in cerebellar Purkinje neurons (PNs), is implicated in the induction of long-term depression. …

[HTML][HTML] Acute cerebellar inflammation and related ataxia: mechanisms and pathophysiology

MSA Parvez, G Ohtsuki - Brain sciences, 2022 - mdpi.com
The cerebellum governs motor coordination and motor learning. Infection with external
microorganisms, such as viruses, bacteria, and fungi, induces the release and production of …

Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells

…, C Piochon, E Teuling, Q He, G Ohtsuki… - Journal of …, 2010 - Soc Neuroscience
Synaptic gain control and information storage in neural networks are mediated by alterations
in synaptic transmission, such as in long-term potentiation (LTP). Here, we show using both …

[PDF][PDF] Similarity of visual selectivity among clonally related neurons in visual cortex

G Ohtsuki, M Nishiyama, T Yoshida, T Murakami… - Neuron, 2012 - cell.com
Neurons in rodent visual cortex are organized in a salt-and-pepper fashion for orientation
selectivity, but it is still unknown how this functional architecture develops. A recent study …

Synergistic excitability plasticity in cerebellar functioning

G Ohtsuki, M Shishikura, A Ozaki - The FEBS Journal, 2020 - Wiley Online Library
The cerebellum, a universal processor for sensory acquisition and internal models, and its
association with synaptic and nonsynaptic plasticity have been envisioned as the biological …

Purkinje cell NMDA receptors assume a key role in synaptic gain control in the mature cerebellum

C Piochon, C Levenes, G Ohtsuki… - Journal of …, 2010 - Soc Neuroscience
A classic view in cerebellar physiology holds that Purkinje cells do not express functional
NMDA receptors and that, therefore, postsynaptic NMDA receptors are not involved in the …

[PDF][PDF] SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells

G Ohtsuki, C Piochon, JP Adelman, C Hansel - Neuron, 2012 - cell.com
Small-conductance Ca 2+ -activated K + channels (SK channels) modulate excitability and
curtail excitatory postsynaptic potentials (EPSPs) in neuronal dendrites. Here, we …