User profiles for Genís Valentín Gesé
 | Genis Valentin GesePostdoctoral researcher, Karolinska Institutet Verified email at ki.se Cited by 161 |
[HTML][HTML] Structural basis for late maturation steps of the human mitoribosomal large subunit
Mitochondrial ribosomes (mitoribosomes) synthesize a critical set of proteins essential for
oxidative phosphorylation. Therefore, mitoribosomal function is vital to the cellular energy …
oxidative phosphorylation. Therefore, mitoribosomal function is vital to the cellular energy …
Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex
FA Weyer, A Gumiero, GV Gese, K Lapouge… - Nature Structural & …, 2017 - nature.com
Cotranslational chaperones assist de novo folding of nascent polypeptides, prevent them
from aggregating and modulate translation. The ribosome-associated complex (RAC) is …
from aggregating and modulate translation. The ribosome-associated complex (RAC) is …
[HTML][HTML] Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain
A Gumiero, C Conz, GV Gesé, Y Zhang… - Nature …, 2016 - nature.com
Cotranslational chaperones assist in de novo folding of nascent polypeptides in all
organisms. In yeast, the heterodimeric ribosome-associated complex (RAC) forms a unique …
organisms. In yeast, the heterodimeric ribosome-associated complex (RAC) forms a unique …
[HTML][HTML] The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb
Y Zhang, G Valentín Gesé, C Conz, K Lapouge… - Nature …, 2020 - nature.com
The conserved ribosome-associated complex (RAC) consisting of Zuo1 (Hsp40) and Ssz1 (non-canonical
Hsp70) acts together with the ribosome-bound Hsp70 chaperone Ssb in de …
Hsp70) acts together with the ribosome-bound Hsp70 chaperone Ssb in de …
[HTML][HTML] Structural inventory of cotranslational protein folding by the eukaryotic RAC complex
M Kišonaitė, K Wild, K Lapouge, GV Gesé… - Nature Structural & …, 2023 - nature.com
The challenge of nascent chain folding at the ribosome is met by the conserved ribosome-associated
complex (RAC), which forms a chaperone triad with the Hsp70 protein Ssb in fungi, …
complex (RAC), which forms a chaperone triad with the Hsp70 protein Ssb in fungi, …
Mass spectrometry of RNA-binding proteins during liquid–liquid phase separation reveals distinct assembly mechanisms and droplet architectures
Liquid–liquid phase separation (LLPS) of heterogeneous ribonucleoproteins (hnRNPs)
drives the formation of membraneless organelles, but structural information about their …
drives the formation of membraneless organelles, but structural information about their …
A dual allosteric pathway drives human mitochondrial Lon
GV Gesé, S Shahzad, C Pardo-Hernández… - bioRxiv, 2021 - biorxiv.org
The hexameric, barrel-forming, AAA+ protease Lon is critical for maintaining mitochondrial
matrix protein homeostasis. Efficient substrate processing by Lon requires the coordinated …
matrix protein homeostasis. Efficient substrate processing by Lon requires the coordinated …
A “grappling hook” interaction connects self-assembly and chaperone activity of Nucleophosmin 1
How the self-assembly of partially disordered proteins generates functional compartments
in the cytoplasm and particularly in the nucleus is poorly understood. Nucleophosmin 1 (NPM1…
in the cytoplasm and particularly in the nucleus is poorly understood. Nucleophosmin 1 (NPM1…
Structural basis for late maturation steps of the human mitoribosomal large subunit
Mitochondrial ribosomes (mitoribosomes) synthezise a critical set of proteins essential for
oxidative phosphorylation. Therefore, their function is vital to cellular energy supply and …
oxidative phosphorylation. Therefore, their function is vital to cellular energy supply and …
A “grappling hook” interaction balances self-assembly and chaperone activity of Nucleophosmin 1
How the self-assembly of partially disordered proteins generates functional compartments
in the cytoplasm and particularly in the nucleus is poorly understood. Nucleophosmin 1 (NPM1…
in the cytoplasm and particularly in the nucleus is poorly understood. Nucleophosmin 1 (NPM1…