Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of a
polyglutamine (polyQ) domain in the N-terminal region of huntingtin (htt). PolyQ expansion …

Pannexin 3 (Panx3) and connexin 43 (Cx43; also known as GJA1) are two major gap
junction proteins expressed in osteoblasts. Here, we studied their functional relationships in …

The protein TRIM5α has multiple roles in antiretroviral defense, but the mechanisms
underlying TRIM5α action are unclear. Here, we employ APEX2-based proteomics to identify …

Ubiquitination of mitochondrial proteins provides a basis for the downstream recruitment of
mitophagy machinery, yet whether ubiquitination of the machinery itself contributes to …

Among the myriad of molecular alterations associated with cancer, loss of the normal tumor
suppressive functions of p53, the “guardian of the genome,” is the most consistent. Thus, the …

Faith must be guided by norms that emphasize justice, communal uplift, and collective well-being.
A Christian concern for justice allows for vision that sees oppression and honors the …

Organic aerosol (OA) particles affect climate forcing and human health, but their sources and
evolution remain poorly characterized. We present a unifying model framework describing …

Background Lower extremity peripheral artery disease is the third leading cause of
atherosclerotic cardiovascular morbidity, following coronary artery disease and stroke. This study …

Information on the evolution, taxonomy, morphology, anatomy, physiology and genetics of
grapevines has been scarce and thinly spread in the literature on horticulture and the plant …

Genetic association studies have identified 21 loci associated with atopic dermatitis risk
predominantly in populations of European ancestry. To identify further susceptibility loci for this …