In adult rodents, neurons are continually generated in the subventricular zone of the forebrain,
from where they migrate tangentially toward the olfactory bulb, the only known target for …

Programmed cell death in animals is usually associated with apoptotic morphology and
requires caspase activation. Necrosis and caspase-independent cell death have been reported, …

Functional properties of the neural cell adhesion molecule (NCAM) are strongly influenced
by polysialylation. We used gene-targeting to generate mice lacking ST8SiaIV/PST-1, one of …

Brain gliomas are highly epileptogenic. Excitatory glutamatergic mechanisms are involved
in the generation of epileptic activities in the neocortex surrounding gliomas. However, …

Cell adhesion molecules (CAMs) are known to be involved in a variety of developmental
processes that play key roles in the establishment of synaptic connectivity during embryonic …

In vertebrates, interneurons of the olfactory bulb (OB) are generated postnatally and
throughout life at the subventricular zone of the forebrain. The neuronal precursors migrate …

Phenobarbital produces its anti-epileptic actions by increasing the inhibitory drive of γ-aminobutyric
acid. However, following recurrent seizures, γ-aminobutyric acid excites neurons …

Actin polymerization plays a critical role in activated T lymphocytes both in regulating T cell
receptor (TCR)-induced immunological synapse (IS) formation and signaling. Using gene …

We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-inhibitory
shift during delivery is abolished in the valproate and fragile X rodent models of …

The neural cell adhesion molecule (NCAM), probably the best characterized and most abundant
cell adhesion molecule on neurons, is thought to be a major regulator of axonal growth …