Neuroblastoma is a childhood cancer that can be inherited, but the genetic aetiology is largely
unknown. Here we show that germline mutations in the anaplastic lymphoma kinase (ALK…

Background Neuroblastoma is a childhood tumor derived from cells of the neural crest, with
a widely variable outcome. Differences in the behavior and prognosis of the tumor suggest …

Purpose: Activating mutations of the anaplastic lymphoma kinase (ALK) were recently
described in neuroblastoma. We carried out a meta-analysis of 709 neuroblastoma tumors to …

Background High-dose chemotherapy with haemopoietic stem-cell rescue improves event-free
survival in patients with high-risk neuroblastoma; however, which regimen has the …

Background Neuroblastoma tumor cells are assumed to originate from primitive neuroblasts
giving rise to the sympathetic nervous system. Because these precursor cells are not …

Purpose Neuroblastoma is a genetically heterogeneous pediatric tumor with a remarkably
variable clinical behavior ranging from widely disseminated disease to spontaneous …

Background More accurate prognostic assessment of patients with neuroblastoma is required
to better inform the choice of risk-related therapy. The aim of this study is to develop and …

Amplification of the proto-oncogene MYCN is a strong adverse prognostic factor in neuroblastoma
patients in all tumor stages. The status of the MYCN gene has become an important …

Purpose To reduce the incidence of febrile neutropenia during rapid COJEC (cisplatin,
vincristine, carboplatin, etoposide, and cyclophosphamide given in a rapid delivery schedule) …

Cancer is a life-threatening disease world-wide and colorectal cancer is the second common
cause of cancer mortality. The interaction between tumor cells and stromal cells plays a …