Orphan nuclear receptors, in a manner comparable to classic steroid hormone receptors,
regulate key developmental and physiological processes. However, the lack of appropriate …

Nuclear receptors can activate diverse biological pathways within a target cell in response
to their cognate ligands, but how this compartmentalization is achieved at the level of gene …

Posterior fossa A (PFA) ependymomas are lethal malignancies of the hindbrain in infants and
toddlers. Lacking highly recurrent somatic mutations, PFA ependymomas are proposed to …

The identification of regulatory regions is one of the most important and challenging problems
toward the functional annotation of the human genome. In higher eukaryotes, transcription-…

Oestrogen-related receptors (ERRs) are orphan nuclear receptors that were initially investigated
in breast cancer because of their structural relationship to oestrogen receptors. Recent …

Posttranslational modifications are instrumental to achieve gene- and tissue-specific
regulatory outcomes by transcription factors. Nuclear receptors are dynamically modulated by …

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the
worst prognosis and few effective therapies. Here we identified MS023, an inhibitor of type I …

Estrogen-related receptor α (ERRα) is an orphan nuclear receptor, the expression of which
correlates with negative prognosis in breast cancer. ERRα shares functional features with the …

Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development
of resistance to chemotherapy affecting over 30% of patients. New therapeutics and …

Background Glutamine metabolism is a central metabolic pathway in cancer. Recently, reductive
carboxylation of glutamine for lipogenesis has been shown to constitute a key anabolic …