Psychedelics are a broad class of drugs defined by their ability to induce an altered state of
consciousness 1 , 2 . These drugs have been used for millennia in both spiritual and …

Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity …

Omics data contain signals from the molecular, physical, and kinetic inter- and intracellular
interactions that control biological systems. Matrix factorization (MF) techniques can reveal …

The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification. …

Single-cell technologies are emerging as powerful tools for cancer research. These technologies
characterize the molecular state of each cell within a tumor, enabling new exploration …

Analysis of gene expression in single cells allows for decomposition of cellular states as low-dimensional
latent spaces. However, the interpretation and validation of these spaces …

Cancer is a complex disease, driven by aberrant activity in numerous signaling pathways in
even individual malignant cells. Epigenetic changes are critical mediators of these functional …

Parallel processing circuits are thought to dramatically expand the network capabilities of the
nervous system. Magnocellular and parvocellular oxytocin neurons have been proposed to …

The mammalian CNS is capable of tolerating chronic hypoxia, but cell type-specific responses
to this stress have not been systematically characterized. In the Norrin KO (Ndp KO ) …

Convergence science teams integrating clinical, biological, engineering, and computational
expertise are inventing new forecast systems to monitor and predict evolutionary changes in …