User profiles for Genevieve L Wojcik
Genevieve L. WojcikAssistant Professor of Epidemiology, Johns Hopkins Bloomberg School of Public Health Verified email at jhu.edu Cited by 4204 |
Genetic analyses of diverse populations improves discovery for complex traits
Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …
biology of complex traits, drug development and clinical guidelines. However, the majority …
[PDF][PDF] Human demographic history impacts genetic risk prediction across diverse populations
The vast majority of genome-wide association studies (GWASs) are performed in Europeans,
and their transferability to other populations is dependent on many factors (eg, linkage …
and their transferability to other populations is dependent on many factors (eg, linkage …
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
We report a genome-wide association study (GWAS) of coronary artery disease (CAD)
incorporating nearly a quarter of a million cases, in which existing studies are integrated with data …
incorporating nearly a quarter of a million cases, in which existing studies are integrated with data …
Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals
Individuals of admixed ancestries (for example, African Americans) inherit a mosaic of
ancestry segments (local ancestry) originating from multiple continental ancestral populations. …
ancestry segments (local ancestry) originating from multiple continental ancestral populations. …
Improving reporting standards for polygenic scores in risk prediction studies
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association
studies, can bridge the gap between initial discovery efforts and clinical applications for the …
studies, can bridge the gap between initial discovery efforts and clinical applications for the …
Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts
Chinese translation Background: Hepatitis C virus (HCV) infections occur worldwide and
either spontaneously resolve or persist and markedly increase the person's lifetime risk for …
either spontaneously resolve or persist and markedly increase the person's lifetime risk for …
Native American gene flow into Polynesia predating Easter Island settlement
…, JR Homburger, GL Wojcik, KC Barnes, L Herrera… - Nature, 2020 - nature.com
The possibility of voyaging contact between prehistoric Polynesian and Native American
populations has long intrigued researchers. Proponents have pointed to the existence of New …
populations has long intrigued researchers. Proponents have pointed to the existence of New …
[HTML][HTML] Mexican Biobank advances population and medical genomics of diverse ancestries
Latin America continues to be severely underrepresented in genomics research, and fine-scale
genetic histories and complex trait architectures remain hidden owing to insufficient data …
genetic histories and complex trait architectures remain hidden owing to insufficient data …
Including multiracial individuals is crucial for race, ethnicity and ancestry frameworks in genetics and genomics
Current ontologies of race, ethnicity and genetic ancestry rely on categorization, but have
limitations — as exemplified by multiracial individuals. We argue that including these …
limitations — as exemplified by multiracial individuals. We argue that including these …
[PDF][PDF] Toward a fine-scale population health monitoring system
Understanding population health disparities is an essential component of equitable precision
health efforts. Epidemiology research often relies on definitions of race and ethnicity, but …
health efforts. Epidemiology research often relies on definitions of race and ethnicity, but …