User profiles for Genevieve L Wojcik

Genevieve L. Wojcik

Assistant Professor of Epidemiology, Johns Hopkins Bloomberg School of Public Health
Verified email at jhu.edu
Cited by 4204

Genetic analyses of diverse populations improves discovery for complex traits

GL Wojcik, M Graff, KK Nishimura, R Tao, J Haessler… - Nature, 2019 - nature.com
Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …

[PDF][PDF] Human demographic history impacts genetic risk prediction across diverse populations

AR Martin, CR Gignoux, RK Walters, GL Wojcik… - The American Journal of …, 2017 - cell.com
The vast majority of genome-wide association studies (GWASs) are performed in Europeans,
and their transferability to other populations is dependent on many factors (eg, linkage …

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

…, D Klarin, MG Levin, N Sinnott-Armstrong, GL Wojcik… - Nature medicine, 2022 - nature.com
We report a genome-wide association study (GWAS) of coronary artery disease (CAD)
incorporating nearly a quarter of a million cases, in which existing studies are integrated with data …

Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals

…, SS Rich, JI Rotter, HE Wheeler, GL Wojcik… - Nature …, 2023 - nature.com
Individuals of admixed ancestries (for example, African Americans) inherit a mosaic of
ancestry segments (local ancestry) originating from multiple continental ancestral populations. …

Improving reporting standards for polygenic scores in risk prediction studies

…, P Kraft, JAL MacArthur, M Inouye, GL Wojcik - Nature, 2021 - nature.com
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association
studies, can bridge the gap between initial discovery efforts and clinical applications for the …

Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts

P Duggal, CL Thio, GL Wojcik, JJ Goedert… - Annals of internal …, 2013 - acpjournals.org
Chinese translation Background: Hepatitis C virus (HCV) infections occur worldwide and
either spontaneously resolve or persist and markedly increase the person's lifetime risk for …

Native American gene flow into Polynesia predating Easter Island settlement

…, JR Homburger, GL Wojcik, KC Barnes, L Herrera… - Nature, 2020 - nature.com
The possibility of voyaging contact between prehistoric Polynesian and Native American
populations has long intrigued researchers. Proponents have pointed to the existence of New …

[HTML][HTML] Mexican Biobank advances population and medical genomics of diverse ancestries

…, A Cortés, V Acuña-Alonzo, CR Gignoux, GL Wojcik… - Nature, 2023 - nature.com
Latin America continues to be severely underrepresented in genomics research, and fine-scale
genetic histories and complex trait architectures remain hidden owing to insufficient data …

Including multiracial individuals is crucial for race, ethnicity and ancestry frameworks in genetics and genomics

DO Martschenko, H Wand, JL Young, GL Wojcik - Nature genetics, 2023 - nature.com
Current ontologies of race, ethnicity and genetic ancestry rely on categorization, but have
limitations — as exemplified by multiracial individuals. We argue that including these …

[PDF][PDF] Toward a fine-scale population health monitoring system

…, BS Glicksberg, D Torre, A Moscati, GL Wojcik… - Cell, 2021 - cell.com
Understanding population health disparities is an essential component of equitable precision
health efforts. Epidemiology research often relies on definitions of race and ethnicity, but …