Patients with dementia present epilepsy more frequently than the general population. Seizures
are more common in patients with Alzheimer’s disease (AD), dementia with Lewy bodies (…

Autism spectrum disorders are early onset neurodevelopmental disorders characterized by
deficits in social communication and restricted repetitive behaviors, yet they are quite …

Lafora disease (LD) is a rare adolescent-onset progressive myoclonic epilepsy caused by
loss-of-function mutations either in the EPM2A gene encoding laforin or in the EPM2B gene …

Objective To search for new therapies aimed at ameliorating the neurologic symptoms and
epilepsy developing in patients with Lafora disease. Methods Lafora disease is caused by …

Lafora disease is a rare form of inherited progressive myoclonus epilepsy caused by mutations
in the EPM2A gene encoding laforin, or in the EPM2B gene, which encodes malin. It is …

Epilepsy is a chronic brain disease and, considering the amount of people affected of all
ages worldwide, one of the most common neurological disorders. Over 20 novel antiseizure …

Mutations in the EPM2A and EPM2B genes, encoding laforin and malin proteins respectively,
are responsible for Lafora disease, a fatal form of progressive myoclonus epilepsy with …

Much of our understanding of the intracellular regulation of macroautophagy/autophagy
comes from in vitro studies. However, there remains a paucity of knowledge about how this …

… Sánchez-Elexpuru is supported by a fellowship from the Fundacion Conchita Rabago. The
authors have reported … Villalba-Orero and Sánchez-Elexpuru contributed equally to this work. …

Multiple sulfatase deficiency (MSD) is a rare recessively inherited Mendelian disorder that
manifests with developmental delay, neurodegeneration, skeletal deformities, facial …