In interphase, the human genome sequence folds in three dimensions into a rich variety of
locus-specific contact patterns. Cohesin and CTCF (CCCTC-binding factor) are key regulators…

Chromosome organization poses a remarkable physical problem with many biological
consequences: How can molecular interactions between proteins at the nanometer scale …

Topologically associating domains (TADs) are fundamental structural and functional building
blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain …

Extracting biologically meaningful information from chromosomal interactions obtained with
genome-wide chromosome conformation capture (3C) analyses requires the elimination of …

The rapid growth of cancer genome structural information provides an opportunity for a
better understanding of the mutational mechanisms of genomic alterations in cancer and the …

Imaging and chromosome conformation capture studies have revealed several layers of
chromosome organization, including segregation into megabase-sized active and inactive …

Mitotic chromosomes are among the most recognizable structures in the cell, yet for over a
century their internal organization remains largely unsolved. We applied chromosome …

Metazoan genomes are spatially organized at multiple scales, from packaging of DNA around
individual nucleosomes to segregation of whole chromosomes into distinct territories 1 , 2 …

Eukaryotic chromatin, is far from being simply a randomly arranged polymer in the cell nucleus.
Rather, Hi-C and imaging reveal a high degree of spatial organization on various length …

The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic
and inactive heterochromatic regions of the genome 1 , 2 . In conventional nuclei, …