[HTML][HTML] SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

…, KW Bock, M Minai, BM Nagata, GB Hutchinson… - Nature, 2020 - nature.com
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to
control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have …

Quadrivalent influenza nanoparticle vaccines induce broad protection

…, D Ellis, RA Gillespie, GB Hutchinson… - Nature, 2021 - nature.com
Influenza vaccines that confer broad and durable protection against diverse viral strains
would have a major effect on global health, as they would lessen the need for annual vaccine …

[HTML][HTML] A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher …

…, CW Chao, Y Tsybovsky, OM Abiona, GB Hutchinson… - Scientific reports, 2020 - nature.com
Antigens displayed on self-assembling nanoparticles can stimulate strong immune responses
and have been playing an increasingly prominent role in structure-based vaccines. …

Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

…, JA Fallas, W Sheffler, J Copps, D Ellis, GB Hutchinson… - Elife, 2020 - elifesciences.org
Multivalent presentation of viral glycoproteins can substantially increase the elicitation of
antigen-specific antibodies. To enable a new generation of anti-viral vaccines, we designed self…

[HTML][HTML] Validation of a SARS-CoV-2 spike protein ELISA for use in contact investigations and serosurveillance

…, MAU Rasheed, S Moye, O Abiona, GB Hutchinson… - Biorxiv, 2020 - ncbi.nlm.nih.gov
Since emergence of SARS-CoV-2 in late 2019, there has been a critical need to understand
prevalence, transmission patterns, to calculate the burden of disease and case fatality rates. …

[HTML][HTML] Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera

GB Hutchinson, OM Abiona, CT Ziwawo… - Nature …, 2023 - nature.com
Multivalent antigen display is a fast-growing area of interest toward broadly protective
vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer …

[HTML][HTML] Structure-based design of Nipah virus vaccines: a generalizable approach to paramyxovirus immunogen development

…, AL Chamberlain, ST Nugent, GB Hutchinson… - Frontiers in …, 2020 - frontiersin.org
Licensed vaccines or therapeutics are rarely available for pathogens with epidemic or
pandemic potential. Developing interventions for specific pathogens and defining generalizable …

[HTML][HTML] Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses

S Boyoglu-Barnum, GB Hutchinson… - Nature …, 2020 - nature.com
The conserved hemagglutinin (HA) stem has been a focus of universal influenza vaccine
efforts. Influenza A group 1 HA stem-nanoparticles have been demonstrated to confer …

[HTML][HTML] Chimeric fusion (F) and attachment (G) glycoprotein antigen delivery by mRNA as a candidate Nipah vaccine

…, Y Tsybovsky, D Nair, GB Hutchinson… - Frontiers in …, 2021 - frontiersin.org
Nipah virus (NiV) represents a significant pandemic threat with zoonotic transmission from
bats-to-humans with almost annual regional outbreaks characterized by documented human-…

Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines

…, D Ellis, RA Gillespie, GB Hutchinson… - bioRxiv, 2020 - biorxiv.org
Influenza vaccines that confer broad and durable protection against diverse virus strains
would have a major impact on global health. However, next-generation vaccine design efforts …