[HTML][HTML] Skin microbiome surveys are strongly influenced by experimental design
JS Meisel, GD Hannigan, AS Tyldsley… - Journal of Investigative …, 2016 - Elsevier
Culture-independent studies to characterize skin microbiota are increasingly common, due
in part to affordable and accessible sequencing and analysis platforms. Compared to culture-…
in part to affordable and accessible sequencing and analysis platforms. Compared to culture-…
The human skin double-stranded DNA virome: topographical and temporal diversity, genetic enrichment, and dynamic associations with the host microbiome
Viruses make up a major component of the human microbiota but are poorly understood in
the skin, our primary barrier to the external environment. Viral communities have the potential …
the skin, our primary barrier to the external environment. Viral communities have the potential …
A deep learning genome-mining strategy for biosynthetic gene cluster prediction
GD Hannigan, D Prihoda, A Palicka… - Nucleic acids …, 2019 - academic.oup.com
Natural products represent a rich reservoir of small molecule drug candidates utilized as
antimicrobial drugs, anticancer therapies, and immunomodulatory agents. These molecules are …
antimicrobial drugs, anticancer therapies, and immunomodulatory agents. These molecules are …
Diagnostic potential and interactive dynamics of the colorectal cancer virome
GD Hannigan, MB Duhaime, MT Ruffin IV… - MBio, 2018 - Am Soc Microbiol
Human viruses (those that infect human cells) have been associated with many cancers,
largely due to their mutagenic and functionally manipulative abilities. Despite this, cancer …
largely due to their mutagenic and functionally manipulative abilities. Despite this, cancer …
Microbial ecology of the skin in the era of metagenomics and molecular microbiology
GD Hannigan, EA Grice - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
The skin is the primary physical barrier between the body and the external environment and
is also a substrate for the colonization of numerous microbes. Previously, dermatological …
is also a substrate for the colonization of numerous microbes. Previously, dermatological …
[HTML][HTML] The application potential of machine learning and genomics for understanding natural product diversity, chemistry, and therapeutic translatability
…, DJ Hazuda, DA Bitton, GD Hannigan - Natural Product …, 2021 - pubs.rsc.org
Covering: up to the end of 2020. The machine learning field can be defined as the study
and application of algorithms that perform classification and prediction tasks through pattern …
and application of algorithms that perform classification and prediction tasks through pattern …
Current concepts and ongoing research in the prevention and treatment of open fracture infections
Significance: Open fractures are fractures in which the bone has violated the skin and soft
tissue. Because of their severity, open fractures are associated with complications that can …
tissue. Because of their severity, open fractures are associated with complications that can …
[HTML][HTML] Biogeography and environmental conditions shape bacteriophage-bacteria networks across the human microbiome
GD Hannigan, MB Duhaime, D Koutra… - PLoS computational …, 2018 - journals.plos.org
Viruses and bacteria are critical components of the human microbiome and play important
roles in health and disease. Most previous work has relied on studying bacteria and viruses …
roles in health and disease. Most previous work has relied on studying bacteria and viruses …
Culture‐independent pilot study of microbiota colonizing open fractures and association with severity, mechanism, location, and complication from presentation to …
GD Hannigan, BP Hodkinson… - Journal of …, 2014 - Wiley Online Library
Precise identification of bacteria associated with post‐injury infection, co‐morbidities, and
outcomes could have a tremendous impact in the management and treatment of open fractures…
outcomes could have a tremendous impact in the management and treatment of open fractures…
[HTML][HTML] Evolutionary and functional implications of hypervariable loci within the skin virome
Localized genomic variability is crucial for the ongoing conflicts between infectious microbes
and their hosts. An understanding of evolutionary and adaptive patterns associated with …
and their hosts. An understanding of evolutionary and adaptive patterns associated with …