[HTML][HTML] Skin microbiome surveys are strongly influenced by experimental design

JS Meisel, GD Hannigan, AS Tyldsley… - Journal of Investigative …, 2016 - Elsevier
Culture-independent studies to characterize skin microbiota are increasingly common, due
in part to affordable and accessible sequencing and analysis platforms. Compared to culture-…

The human skin double-stranded DNA virome: topographical and temporal diversity, genetic enrichment, and dynamic associations with the host microbiome

GD Hannigan, JS Meisel, AS Tyldsley, Q Zheng… - MBio, 2015 - Am Soc Microbiol
Viruses make up a major component of the human microbiota but are poorly understood in
the skin, our primary barrier to the external environment. Viral communities have the potential …

A deep learning genome-mining strategy for biosynthetic gene cluster prediction

GD Hannigan, D Prihoda, A Palicka… - Nucleic acids …, 2019 - academic.oup.com
Natural products represent a rich reservoir of small molecule drug candidates utilized as
antimicrobial drugs, anticancer therapies, and immunomodulatory agents. These molecules are …

Diagnostic potential and interactive dynamics of the colorectal cancer virome

GD Hannigan, MB Duhaime, MT Ruffin IV… - MBio, 2018 - Am Soc Microbiol
Human viruses (those that infect human cells) have been associated with many cancers,
largely due to their mutagenic and functionally manipulative abilities. Despite this, cancer …

Microbial ecology of the skin in the era of metagenomics and molecular microbiology

GD Hannigan, EA Grice - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
The skin is the primary physical barrier between the body and the external environment and
is also a substrate for the colonization of numerous microbes. Previously, dermatological …

[HTML][HTML] The application potential of machine learning and genomics for understanding natural product diversity, chemistry, and therapeutic translatability

…, DJ Hazuda, DA Bitton, GD Hannigan - Natural Product …, 2021 - pubs.rsc.org
Covering: up to the end of 2020. The machine learning field can be defined as the study
and application of algorithms that perform classification and prediction tasks through pattern …

Current concepts and ongoing research in the prevention and treatment of open fracture infections

GD Hannigan, N Pulos, EA Grice… - Advances in wound care, 2015 - liebertpub.com
Significance: Open fractures are fractures in which the bone has violated the skin and soft
tissue. Because of their severity, open fractures are associated with complications that can …

[HTML][HTML] Biogeography and environmental conditions shape bacteriophage-bacteria networks across the human microbiome

GD Hannigan, MB Duhaime, D Koutra… - PLoS computational …, 2018 - journals.plos.org
Viruses and bacteria are critical components of the human microbiome and play important
roles in health and disease. Most previous work has relied on studying bacteria and viruses …

Culture‐independent pilot study of microbiota colonizing open fractures and association with severity, mechanism, location, and complication from presentation to …

GD Hannigan, BP Hodkinson… - Journal of …, 2014 - Wiley Online Library
Precise identification of bacteria associated with post‐injury infection, co‐morbidities, and
outcomes could have a tremendous impact in the management and treatment of open fractures…

[HTML][HTML] Evolutionary and functional implications of hypervariable loci within the skin virome

GD Hannigan, Q Zheng, JS Meisel, SS Minot… - PeerJ, 2017 - peerj.com
Localized genomic variability is crucial for the ongoing conflicts between infectious microbes
and their hosts. An understanding of evolutionary and adaptive patterns associated with …