Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin
into chromatin loops 1 , 2 and topologically associated domains 3 , 4 , 5 , 6 , which have …

The upper gastrointestinal tract, consisting of the esophagus, stomach, and duodenum,
controls food transport, digestion, nutrient uptake, and hormone production. By single-cell …

The transcription factor Pax5 represses B lineage-inappropriate genes and activates B cell-specific
genes in B lymphocytes. Here we have identified 170 Pax5-activated genes. …

Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops. “Loop extrusion” can be impeded by chromatin-bound factors, such as CTCF, …

Enteroendocrine cells (EECs) sense intestinal content and release hormones to regulate
gastrointestinal activity, systemic metabolism, and food intake. Little is known about the …

Cohesion between sister chromatids is established during DNA replication but needs to be
maintained to enable proper chromosome–spindle attachments in mitosis or meiosis. …

10.7554/eLife.46269.001 The organisation of mammalian genomes into loops and topologically
associating domains (TADs) contributes to chromatin structure, gene expression and …

Barrett’s esophagus (BE) is categorized, based on morphological appearance, into different
stages, which correlate with the risk of developing esophageal adenocarcinoma. More …

Loss of the cell–cell adhesion protein E‐cadherin underlies the development of diffuse‐type
gastric cancer (DGC), which is characterized by the gradual accumulation of tumor cells …

Obesity is a modifiable risk factor in cancer development, especially for gastrointestinal
cancer. While the etiology of colorectal cancer is well characterized by the adenoma-carcinoma …