Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of
dopaminergic neurons in the substantia nigra. We previously mapped a locus for a rare …

Mutations of the α-synuclein gene 1 , 2 have been identified in some familial forms of
Parkinson's disease, and α-synuclein protein has been shown to accumulate in the brains of …

Autosomal dominant optic atrophy (ADOA) is the most prevalent hereditary optic neuropathy
resulting in progressive loss of visual acuity, centrocoecal scotoma and bilateral temporal …

The causes of amyotrophic lateral sclerosis (ALS), a devastating human neurodegenerative
disease, are poorly understood, although the protein TDP-43 has been suggested to have a …

The gene for spinocerebellar ataxia type 2 (SCA2) has been mapped to 12q24.1. A1.1–megabase
contig in the candidate region was assembled in P1 artificial chromosome and …

Degeneration of dopaminergic neurons in the substantia nigra is characteristic for Parkinson's
disease (PD), the second most common neurodegenerative disorder. Mitochondrial …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease that
is characterized by motor neuron loss and that leads to paralysis and death 2–5 years after …

Background Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown
etiology. We have previously shown that loss-of-function mutations of the mitochondrial …

The spinocerebellar ataxias type 1 (SCA1), 2 (SCA2), 3 (SCA3), 6 (SCA6) and 7 (SCA7) are
genetically defined autosomal dominantly inherited progressive cerebellar ataxias (ADCAs). …

Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall;
their hemorrhage commonly results in severe neurologic impairment and death. We report a …