User profiles for Georg Köhr
Georg KoehrCentral Institute of Mental Health Verified email at zi-mannheim.de Cited by 7925 |
Role of Heteromer Formation in GABAB Receptor Function
Recently, GBR1, a seven-transmembrane domain protein with high affinity for γ-aminobutyric
acid (GABA) B receptor antagonists, was identified. Here, a GBR1-related protein, GBR2, …
acid (GABA) B receptor antagonists, was identified. Here, a GBR1-related protein, GBR2, …
NMDA receptor function: subunit composition versus spatial distribution
G Köhr - Cell and tissue research, 2006 - Springer
NMDA receptors (NMDARs) play a pivotal role in the regulation of neuronal communication
and synaptic function in the central nervous system. The subunit composition and …
and synaptic function in the central nervous system. The subunit composition and …
Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation
…, V Pawlak, PH Seeburg, Ø Hvalby, G Köhr - Journal of …, 2005 - Soc Neuroscience
NMDA receptor (NMDAR) 2A (NR2A)- and NR2B-type NMDARs coexist in synapses of CA1
pyramidal cells. Recent studies using pharmacological blockade of NMDAR subtypes …
pyramidal cells. Recent studies using pharmacological blockade of NMDAR subtypes …
MicroRNA loss enhances learning and memory in mice
Dicer-dependent noncoding RNAs, including microRNAs (miRNAs), play an important role
in a modulation of translation of mRNA transcripts necessary for differentiation in many cell …
in a modulation of translation of mRNA transcripts necessary for differentiation in many cell …
[HTML][HTML] Triheteromeric NR1/NR2A/NR2B receptors constitute the major N-methyl-D-aspartate receptor population in adult hippocampal synapses
C Rauner, G Köhr - Journal of Biological Chemistry, 2011 - ASBMB
NMDA receptors (NMDARs), fundamental to learning and memory and implicated in certain
neurological disorders, are heterotetrameric complexes composed of two NR1 and two NR2 …
neurological disorders, are heterotetrameric complexes composed of two NR1 and two NR2 …
[HTML][HTML] Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor
We studied the role of PDZ proteins GRIP, ABP, and PICK1 in GluR2 AMPA receptor trafficking.
An epitope-tagged MycGluR2 subunit, when expressed in hippocampal cultured neurons…
An epitope-tagged MycGluR2 subunit, when expressed in hippocampal cultured neurons…
NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory
…, R Sprengel, PH Seeburg, G Köhr… - Journal of …, 2008 - Soc Neuroscience
NMDA receptors (NMDARs) containing NR2A (ε1) subunits are key contributors to hippocampal
long-term potentiation (LTP) induction in adult animals and have therefore been widely …
long-term potentiation (LTP) induction in adult animals and have therefore been widely …
C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors
…, MB Kennedy, PH Seeburg, G Köhr - Journal of …, 2000 - Soc Neuroscience
NMDA receptors interact via the extended intracellular C-terminal domain of the NR2
subunits with constituents of the postsynaptic density for purposes of retention, clustering, and …
subunits with constituents of the postsynaptic density for purposes of retention, clustering, and …
NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in d‐2‐hydroxyglutaric aciduria
…, J Krieglstein, GF Hoffmann, G Köhr - European Journal of …, 2002 - Wiley Online Library
The inherited neurometabolic disease d‐2‐hydroxyglutaric aciduria is complicated by
progressive neurodegeneration of vulnerable brain regions during infancy and early childhood, …
progressive neurodegeneration of vulnerable brain regions during infancy and early childhood, …
Excitotoxicity in vitro by NR2A-and NR2B-containing NMDA receptors
…, I Coserea, V Pawlak, EC Fuchs, G Köhr… - …, 2007 - Elsevier
Excitotoxicity, exacerbating acute brain damage from brain trauma or stroke, is mediated in
part by excessive Ca 2+ -influx from prolonged NMDA receptor activation. However, the …
part by excessive Ca 2+ -influx from prolonged NMDA receptor activation. However, the …