User profiles for Georg K. Gerber
Georg GerberAssistant Professor of Pathology, Harvard Medical School Verified email at bwh.harvard.edu Cited by 11624 |
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as …
Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as …
[HTML][HTML] Alterations of the human gut microbiome in multiple sclerosis
The gut microbiome plays an important role in immune function and has been implicated in
several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut …
several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut …
[PDF][PDF] Diet dominates host genotype in shaping the murine gut microbiota
Mammals exhibit marked interindividual variations in their gut microbiota, but it remains
unclear if this is primarily driven by host genetics or by extrinsic factors like dietary intake. To …
unclear if this is primarily driven by host genetics or by extrinsic factors like dietary intake. To …
Computational discovery of gene modules and regulatory networks
Z Bar-Joseph, GK Gerber, TI Lee, NJ Rinaldi… - Nature …, 2003 - nature.com
We describe an algorithm for discovering regulatory networks of gene modules, GRAM (Genetic
Regulatory Modules), that combines information from genome-wide location and …
Regulatory Modules), that combines information from genome-wide location and …
A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis
BACKGROUND: Commensal microbiota play a critical role in maintaining oral tolerance.
The effect of food allergy on the gut microbial ecology remains unknown. OBJECTIVE: We …
The effect of food allergy on the gut microbial ecology remains unknown. OBJECTIVE: We …
[PDF][PDF] Dynamic modulation of the gut microbiota and metabolome by bacteriophages in a mouse model
The human gut microbiome is comprised of densely colonizing microorganisms including
bacteriophages, which are in dynamic interaction with each other and the mammalian host. To …
bacteriophages, which are in dynamic interaction with each other and the mammalian host. To …
Continuous representations of time-series gene expression data
Z Bar-Joseph, GK Gerber, DK Gifford… - Journal of …, 2003 - liebertpub.com
We present algorithms for time-series gene expression analysis that permit the principled
estimation of unobserved time points, clustering, and dataset alignment. Each expression …
estimation of unobserved time points, clustering, and dataset alignment. Each expression …
Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
Bacteria can be engineered to function as diagnostics or therapeutics in the mammalian gut
but commercial translation of technologies to accomplish this has been hindered by the …
but commercial translation of technologies to accomplish this has been hindered by the …
Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy
The role of dysbiosis in food allergy (FA) remains unclear. We found that dysbiotic fecal
microbiota in FA infants evolved compositionally over time and failed to protect against FA in mice…
microbiota in FA infants evolved compositionally over time and failed to protect against FA in mice…
[HTML][HTML] MDSINE: Microbial Dynamical Systems INference Engine for microbiome time-series analyses
Predicting dynamics of host-microbial ecosystems is crucial for the rational design of
bacteriotherapies. We present MDSINE, a suite of algorithms for inferring dynamical systems …
bacteriotherapies. We present MDSINE, a suite of algorithms for inferring dynamical systems …