The elucidation of the molecular mechanisms by which soluble proteins convert into their
amyloid forms is a fundamental prerequisite for understanding and controlling disorders that …

α-Synuclein (α-syn) is a 140-residue intrinsically disordered protein that is involved in neuronal
and synaptic vesicle plasticity, but its aggregation to form amyloid fibrils is the hallmark of …

The two major forms of the amyloid-beta (Aβ) peptide found in plaques in patients suffering
from Alzheimer’s disease, Aβ40 and Aβ42, only differ by two amino acids in the C-terminal …

Nucleation of new peptide and protein aggregates on the surfaces of amyloid fibrils of the
same peptide or protein has emerged in the past two decades as a major pathway for both the …

Parkinson’s disease is a highly debilitating neurodegenerative condition whose pathological
hallmark is the presence in nerve cells of proteinacious deposits, known as Lewy bodies, …

The self-assembly of α-synuclein is closely associated with Parkinson’s disease and related
syndromes. We show that squalamine, a natural product with known anticancer and antiviral …

Oligomeric species populated during the aggregation of the Aβ42 peptide have been
identified as potent cytotoxins linked to Alzheimer’s disease, but the fundamental molecular …

The clinical and pathological differences between synucleinopathies such as Parkinson’s
disease and multiple system atrophy have been postulated to stem from unique strains of α-…

Both the replication of protein aggregates and their spreading throughout the brain are
implicated in the progression of Alzheimer’s disease (AD). However, the rates of these processes …

The amyloid cascade hypothesis, according to which the self-assembly of amyloid-β peptide
(Aβ) is a causative process in Alzheimer’s disease, has driven many therapeutic efforts for …