Circulation data were gathered by a ship from a 3 × 2 study area adjacent to Western
Australia in 1974–76 and by satellite-tracked buoys from a much larger area in 1975–77. An …

Chromosomal instability in cancer consists of dynamic changes to the number and structure
of chromosomes 1 , 2 . The resulting diversity in somatic copy number alterations (SCNAs) …

Most cancer genomic data are generated from bulk samples composed of mixtures of
cancer subpopulations, as well as normal cells. Subclonal reconstruction methods based on …

Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer
therapy today. However, evolving resistance to one drug may come at a cost of decreased …

The evolution of pediatric solid tumors is poorly understood. There is conflicting evidence of
intra-tumor genetic homogeneity vs. heterogeneity (ITGH) in a small number of studies in …

Both normal tissue development and cancer growth are driven by a branching process of
cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. …

Circulating tumour DNA (ctDNA) allows tracking of the evolution of human cancers at high
resolution, overcoming many limitations of tissue biopsies. However, exploiting ctDNA to …

10.7554/eLife.08711.001 Glioblastoma multiforme (GBM) is the most aggressive human
primary brain cancer. Using a Trp53-deficient mouse model of GBM, we show that genetic …

Genetic and epigenetic variation, together with transcriptional plasticity, contribute to
intratumour heterogeneity 1 . The interplay of these biological processes and their respective …

In October 1987 and March 1988, measurements were taken across the Sahul shelf and the
southwestern end of the Timor Strait to the edge of Indonesian waters. The shipboard …